Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
-
Zhongguo Yi Xue Ke Xue Yuan Xue Bao · Dec 2019
Review[N-methyl-D-aspartate Receptor:Potential Role in TreatingNeuraxial Opioid Induced Pruritus].
Neuraxial opioid administration is one of the most common methods of anesthesia and analgesia,while itching is the most troublesome adverse effect. The current treatments for neuraxial opioid-induced pruritus still have certain limitations. ⋯ Based on our recent findings on N-methyl-D-aspartate(NMDA)receptors and pruritus caused by neuraxial opioids,we provide new ideas for the treatment of itching caused by neuraxial opioids. Since NMDA receptors may play a key role in neuraxial opioid-induced pruritus,NMDA receptor antagonists can have certain therapeutic advantages.