Revista médica de Chile
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Revista médica de Chile · Nov 2020
Case Reports[Cushing syndrome caused by a giant adrenal carcinoma. Report of one case].
We report a previously healthy 34-year-old woman, presenting with a seven-month history of arterial hypertension, amenorrhea, weight gain, facial edema, acne, hirsutism and low back pain. A CT scan showed a right adrenal mass of 18 × 13 × 12.5 cm, and multiple vertebral and rib fractures. The hormonal study confirmed Cushing's Syndrome. ⋯ Study of vertebral fractures with magnetic resonance (MRI) showed crush fractures, without images of metastatic bone lesions. One year after surgery, a CT scan showed no signs of tumor recurrence. The patient was lost from follow-up thereafter.
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Revista médica de Chile · Nov 2020
Clinical features of 47 patients infected with COVID-19 admitted to a Regional Reference Center.
During the first pandemic wave, Covid-19 reached Latin America cities. ⋯ In our regional Center, patients admitted with COVID-19 had usual risk factors and had a prolonged stay. Hospital mortality was associated with immunosuppression and ICU admission.
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Revista médica de Chile · Nov 2020
Case ReportsTrametinib and dabrafenib induced rhabdomyolysis, renal failure, and visual loss. Report of one case.
MEK- and BRAF-inhibitors trametinib and dabrafenib are successfully used for BRAF-mutated, metastasizing melanoma, but these compounds may induce side effects. We report a 50 years old female with BRAF-mutated metastasizing melanoma who received trametinib (2 mg/d) and dabrafenib (200 mg/d) after using interferon without benefit. Shortly after starting trametinib/dabrafenib, she experienced an inability to abduct the left eye. ⋯ She could not eat or drink during four days prior to admission. The patient suspected an adverse effect of trametinib/dabrafenib and discontinued it 2 days prior to admission. Thereafter, she experienced an almost complete remission of the deficits except for ocular muscle weakness and visual impairment.
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Revista médica de Chile · Nov 2020
[The threat of climate change on population health and the urgent need to act].
Climate change is associated with negative health outcomes, such as cardiovascular and respiratory diseases. This article analyses the threat of climate change on population health and the urgent need to implement measures to avoid this damage. Heat vulnerability, heatwave exposures, and wildfire exposure to forest fires have increased in Chile. ⋯ Thus, multidisciplinary and intersectoral mitigation and adaptation policies are needed. Among other elements, mental health impacts of climate change, health education provided by health workers to reduce negative health impacts of climate change, greater engagement of academia to generate evidence useful for policy-making processes and a better articulation between central and local governments should be considered. Finally, achieving a healthy population should be the aim of all these policies and efforts.
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Revista médica de Chile · Nov 2020
[Reliability and construct validity of SF-12 to measure health related quality of life in Chilean subjects].
Health-Related Quality of Life (HRQoL) is understood as a multidimensional variable, mostly measured using the SF-12 questionnaire. However, this measurement doesn't always replicate the factorial structure theoretically expected, hindering potential conclusions. ⋯ The practical importance of these results highlight the need to measure HRQoL using more extensive scales.