Revista médica de Chile
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Revista médica de Chile · Nov 2020
Review[Anti-inflammatory therapies for SARS-COV2 infection from a hematological perspective].
The pathophysiology of the inflammatory profile induced by SARS-COV2 infection has similarities with conditions of immune system activation with cytokine release such as hemophagocytic syndrome and some cases of acute graft-versus-host disease. There are encouraging results of clinical studies, performed with increasingly better methodological quality, supporting the use of targeted and specific anti-inflammatory therapy in selected groups of patients with COVID-19 with severe inflammation. In this review we describe the inflammatory pathophysiology of the disease and the recent findings about its treatment.
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Revista médica de Chile · Nov 2020
Review[Excess mortality during the COVID-19 pandemic, a narrative review].
Capturing all the deaths caused by COVID-19 through epidemiologic surveillance based on individual case notification is difficult, therefore, all-cause excess mortality (EM) is an appropriate measure for geographic comparisons and monitoring of the application of non-pharmacological sanitary measures. This is a narrative review of the literature about the observed EM during the COVID-19 pandemic. A research was made on scientific databases (Google Scholar, Pubmed, Virtual Health Library) using the terms "excess mortality", "excess deaths", "COVID-19", "coronavirus", "SARS-CoV-2". ⋯ They confirm EM in the locations studied, with higher proportion of men and older people and with remarkable spatial heterogeneity. The need to optimize the standardization and updating of mortality registration and reporting mechanisms is highlighted. At a local level, data about EM that will allow these analyses is incipiently becoming available.