Revista médica de Chile
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Revista médica de Chile · Jun 2024
Review Case Reports[Review of Multiple Endocrine Neoplasia Type 1 Based on a Clinical Case].
Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant disease with an estimated prevalence of 2 per 100,000. This disease is caused by a mutation in the tumor suppressor gene MEN1, which is located on chromosome 11 and codifies the menin protein. It is characterized by a predisposition of parathyroids, enteropancreatic, and anterior pituitary tumors, affecting the quality of life and lifespan of those who have the disease. ⋯ Pancreatic and parathyroid surgery were performed, and function substitution therapies were initiated. Discussion: The diagnosis is established in the presence of two or more defining NEM1 tumors or at least one associated with compatible genetic testing or a first-degree relative with a history of MEN1. Screening and surveillance in patients with confirmed MEN1 diagnosis would enable the reduction of the disease burden, with a nonclear impact on lifespan.
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Revista médica de Chile · Jun 2024
Review[Updates in General Management and Frequent Complications Following Adult Liver Transplant].
Liver transplantation (LT) is a cost-effective therapy for advanced liver disease. Although LT significantly improves long-term survival, it requires strict control of immunosuppressants and their potential complications. Several available immunosuppressive drugs include glucocorticoids, calcineurin inhibitors, mycophenolate, mTOR inhibitors, and anti-CD25 antibodies. ⋯ Appropriate treatment of the underlying etiology is essential, especially in autoimmune diseases, hepatitis B and C virus infection. Lifestyle changes must be encouraged in all patients, and alcohol consumption avoided (especially in alcohol use disorder). Due to the increased risk of cancer, neoplasms must be actively monitored, as well as osteoporosis and other metabolic disorders such as diabetes and cardiovascular disease.
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Revista médica de Chile · Jun 2024
Association between body mass index and all-cause mortality in older people: A prospective analysis of the Chilean National Health Survey 2009-2010.
There is a divergence in the results of studies that have explored the association between body mass index (BMI) and health outcomes in different contexts. ⋯ Older people categorized as underweight and obese II had a higher risk of all-cause mortality than their normal-weight peers, regardless of confounding factors.
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Revista médica de Chile · Jun 2024
Case Reports[Granulomas in Intestinal Biopsies? Intestinal Tuberculosis Mimicking Crohn's Disease: A Case Report].
Intestinal tuberculosis is a bacterial infection that represents 10% of extrapulmonary tuberculosis. It is known as the great mimicker due to its clinical presentation similar to other diseases such as Crohn's Disease or Neoplastic Intestinal Disease. ⋯ We present the case of a 57-year-old patient with an initial diagnosis of Crohn's Disease, starting immunosuppressive therapy. After no response to the initial therapy and with a new endoscopic and anatomopathological study, Intestinal Tuberculosis was concluded, which after starting therapy evolved favorably.
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Revista médica de Chile · Jun 2024
Case Reports[Bivalvular Infective Endocarditis with Involvement of the Mitroaortic Fibrosis by Staphylococcus lugdunensis].
Bivalvular infective endocarditis is a clinical presentation that is associated to a greater extent with adverse outcomes. The involvement of the intervalvular mitral-aortic fibrosa is a rare complication associated with high mortality rates, requiring high complexity surgery. We report a case of a young male presenting to the emergency department with bivalvular endocarditis and mitral-aortic intervalvular fibrosa involvement.