Mayo Clinic proceedings
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Mayo Clinic proceedings · Jul 2019
Multicenter StudyCharacterization of the Obese Phenotype of Heart Failure With Preserved Ejection Fraction: A RELAX Trial Ancillary Study.
To characterize the obese heart failure with preserved ejection fraction (HFpEF) phenotype in a multicenter cohort. ⋯ Obese HFpEF is associated with decreased quality of life, worse symptoms of heart failure, greater systemic inflammation, worse exercise capacity, and higher metabolic cost of exertion as compared with nonobese HFpEF. Further study is required to understand the pathophysiology and potential distinct treatments for patients with the obese phenotype of HFpEF.