Mayo Clinic proceedings
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Mayo Clinic proceedings · Apr 2008
Review Meta AnalysisEffect of perioperative insulin infusion on surgical morbidity and mortality: systematic review and meta-analysis of randomized trials.7.
To conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the effect of perioperative insulin infusion on outcomes important to patients. ⋯ Perioperative insulin infusion may reduce mortality but increases hypoglycemia in patients who are undergoing surgery; however, mortality results require confirmation in large and rigorous RCTs.
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Mayo Clinic proceedings · Jan 2007
Review Meta AnalysisTestosterone and cardiovascular risk in men: a systematic review and meta-analysis of randomized placebo-controlled trials.
To conduct a systematic review and meta-analysis of randomized trials that assessed the effect of testosterone use on cardiovascular events and risk factors in men with different degrees of androgen deficiency. ⋯ Currently available evidence weakly supports the inference that testosterone use in men is not associated with important cardiovascular effects. Patients and clinicians need large randomized trials of men at risk for cardiovascular disease to better inform the safety of long-term testosterone use.
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Mayo Clinic proceedings · Sep 2005
Meta Analysis Comparative StudyCiprofloxacin vs an aminoglycoside in combination with a beta-lactam for the treatment of febrile neutropenia: a meta-analysis of randomized controlled trials.
To compare the effectiveness and toxicity of ciprofloxacin vs an aminoglycoside, both in combination with a beta-lactam, for the treatment of febrile neutropenia in the inpatient setting. ⋯ The combination of ciprofloxacin with a beta-actam antibiotic should be considered an important therapeutic option in hospitalized febrile neutropenic patients who have not received a quinolone for prevention of infections and in settings in which quinolone resistance is not common.
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Mayo Clinic proceedings · Dec 2004
Meta Analysis Comparative StudySeizure prophylaxis in patients with brain tumors: a meta-analysis.
To assess whether antiepileptic drugs (AEDs) should be prescribed to patients with brain tumors who have no history of seizures. ⋯ No evidence supports AED prophylaxis with phenobarbital, phenytoin, or valproic acid in patients with brain tumors and no history of seizures, regardless of neoplastic type. Subspecialists who treat patients with brain tumors need more education on this issue. Future randomized controlled trials should address whether any of the newer AEDs are useful for seizure prophylaxis.