Mayo Clinic proceedings
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Mayo Clinic proceedings · Jul 2014
Meta AnalysisTreatment discontinuations with new oral agents for long-term anticoagulation: insights from a meta-analysis of 18 randomized trials including 101,801 patients.
To systematically examine discontinuation rates with new US Food and Drug Administration-approved oral anticoagulants (NOACs) in patients with various indications for long-term anticoagulation. ⋯ Study drug discontinuations with NOACs were not significantly different from those with conventional drugs in treatment of venous thromboembolism/pulmonary embolism and prevention of stroke in patients with atrial fibrillation but were worse in acute coronary syndromes as noted in evidence from contemporary RCTs.
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Mayo Clinic proceedings · Mar 2014
Meta AnalysisA pooled analysis of waist circumference and mortality in 650,000 adults.
To assess the independent effect of waist circumference on mortality across the entire body mass index (BMI) range and to estimate the loss in life expectancy related to a higher waist circumference. ⋯ In white adults, higher waist circumference was positively associated with higher mortality at all levels of BMI from 20 to 50 kg/m(2). Waist circumference should be assessed in combination with BMI, even for those in the normal BMI range, as part of risk assessment for obesity-related premature mortality.
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Mayo Clinic proceedings · Nov 2013
Review Meta AnalysisStatins and cognition: a systematic review and meta-analysis of short- and long-term cognitive effects.
To evaluate the effect of statins on short-term cognitive function and the long-term incidence of dementia. ⋯ In patients without baseline cognitive dysfunction, short-term data are most compatible with no adverse effect of statins on cognition, and long-term data may support a beneficial role for statins in the prevention of dementia.
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Mayo Clinic proceedings · Oct 2013
Review Meta AnalysisEndovascular therapy for acute ischemic stroke: a systematic review and meta-analysis.
To consolidate the evidence from randomized trials for the use of endovascular therapy (ET) in patients with acute ischemic stroke. ⋯ Overall, ET is not superior to IV thrombolysis for acute ischemic strokes (level B recommendation). However, ET showed promise and improved outcomes in patients with severe strokes, but the evidence is limited due to sample size. There is a need for further trials evaluating the role of ET in this high-risk group.
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Mayo Clinic proceedings · Jun 2013
Review Meta AnalysisL-carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis.
To evaluate the effects of L-carnitine compared with placebo or control on morbidity and mortality in the setting of acute myocardial infarction. ⋯ Compared with placebo or control, L-carnitine is associated with a 27% reduction in all-cause mortality, a 65% reduction in VAs, and a 40% reduction in anginal symptoms in patients experiencing an acute myocardial infarction. Further study with large randomized controlled trials of this inexpensive and safe therapy in the modern era is warranted.