East African medical journal
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Multicenter Study
Clinical characteristics of Burkitt's lymphoma seen in Kenyan patients.
To document the clinical features of Burkitt's lymphoma (BL) in the study population. ⋯ The clinical features are protean and BL is a rapidly progressive disease, presenting with swelling, majority in the jaw and abdomen in childhood and young adults. Age, sex and geographical (province) appear to influence the primary site of the disease. Also BL is a differential in many clinical presentations in this childhood setting.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Use of a simple pain model to evaluate analgesic activity of ibuprofen versus paracetamol.
To evaluate the analgesic activity of ibuprofen against paracetamol using a simple pain model. ⋯ Sore throat pain provided a sensitive model to assess the analgesic efficacy of class I analgesics and discriminated between the analgesic efficacy of ibuprofen and paracetamol.
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Multicenter Study Comparative Study
Asphyxia of the newborn in east, central and southern Africa.
Very scanty information is available in East, Central and Southern Africa on the incidence and risk factors associated with asphyxia of the newborn. A multicentre prospective study involving 4267 deliveries in eight countries was undertaken over a three month period, in maternity units of the central hospitals to determine the incidence; maternal, service and logistic risk factors for asphyxia of the newborn as determined by an abnormally low apgar score. 30% of births were by primigravida mothers, of whom 67% were teenagers. A birth by a teenager had a higher risk for low birth weight. ⋯ These should include identification of the at risk mother, proper referral and management while adhering to correct established procedures. There is also need to develop appropriate and relevant technologies for perinatal and neonatal care through research undertaken in the region. It is also concluded that the co-operation and joint effort between the obstetricians, paediatricians and the nursing staff who all contributed to the collection of this data is a cost effective approach to research in perinatal health and consequently in instituting interventions.
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Multicenter Study Clinical Trial
Evaluation of diprivan as an intravenous anaesthetic induction agent: experiences in Nairobi, Kenya.
Diprivan in its emulsion formulation as an intravenous induction agent was studied in 125 patients undergoing general anaesthesia for short duration, minor procedures, at Kenyatta National Hospital, Nairobi, Kenya. The drug was found to be effective as it caused loss of consciousness in all the studied patients within 40 seconds when injected intravenously. The induction period was associated with pain at injection site in 31.2%, some muscle movements in 15.2% and hiccups in 8.8% of all the cases. There was a significant fall in mean arterial blood pressure in all the cases at two minutes after induction of anaesthesia with no observed concomitant changes in pulse rate.