Hiroshima journal of medical sciences
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Hiroshima J. Med. Sci. · Mar 2004
Randomized Controlled Trial Clinical TrialComparative benefit of preemptively applied thiopental for propofol injection pain: the advantage over lidocaine.
Propofol is one of the most frequently applied intravenous anesthetics for the induction of general anesthesia. However, pain on injection of this agent is a considerable problem in daily anesthesia practice because of its severity. Administration of lidocaine prior to propofol injection is a standard technique for reducing the pain on injection. ⋯ Lidocaine failed to influence the incidence of pain (from 86% to 55%), although thiopental significantly decreased it to 40% (25 mg), 21% (50 mg), 12% (50 mg), and 0% (100 mg), respectively. Thiopental (> or =50 mg) decreased both the severity and incidence of pain more effectively than lidocaine. A Hill plot analysis of these data, after rearrangement by patient's body weight, estimated that the half-effective dose (ED50) and the ED99 of this drug to block pain on injection of propofol were 0.6 and 1.4 mg/kg, respectively.