Panminerva medica
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Review Meta Analysis
Applications of cardiotoxicity in breast cancer: a meta-analysis.
Breast cancer is the most common type of cancer in women. Many antineoplastic agents used to treat breast cancer have potentially cardiotoxic effects and may lead to chemotherapy induced cardiomyopathy and heart failure. We conducted a meta-analysis to clarify the applications of cardiotoxicity in breast cancer. ⋯ In this meta-analysis, there was evidence indicated that there was not a significant decrease on LVEF and EF in patients who received trastuzumab plus lapatinib and trastuzumab plus pertuzumab combination. Our study suggests that the combination of two anti-HER2 agents does not significantly increase the risk for adverse compared with anti-HER2 monotherapy in patients with adequate cardiac function prior to start of therapy.
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Meta Analysis
The association of HOTAIR expression with clinicopathological features and prognosis in gastric cancer patients.
A number of studies in gastric carcinoma have demonstrated that cancerous tissues have a significant higher HOTAIR level than that in noncancerous tissues. Overexpression of HOTAIR is associated with the development in gastric cancer. ⋯ There is an association between HOTAIR expression and clinicopathological features and prognosis in gastric cancer patients. High expression of HOTAIR in cancerous tissue could predict poor clinical outcome in gastric cancer, suggesting HOTAIR abundance may serve as a novel candidate biomarker for the clinical outcome in gastric cancers.