Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
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Zhongguo Ying Yong Sheng Li Xue Za Zhi · Jun 2017
[The effects of NOX4 and TGF-βinvolved in airway remodeling of Chronic Obstructive Pulmonary Disease].
To investigate the role of nicotinamide adenine dinucleotide phosphate 4 (NADPH4,NOX4) and transforming growth factor-beta (TGF-β) involve in pathogenesis of airway remodeling in chronic obstructive pulmonary disease (COPD). ⋯ ①The airway remodeling of COPD is characterized by increasing hyperplasia of small airway smooth muscle.②Remodeling of airway smooth muscle associats with severity of airflow limitation in COPD patients. ③The expressions of NOX4, TGF-β and α-SMA in COPD epithelial cells and small airway smooth muscle cells are significantly enhanced. The expressions of NOX4, α-SMA and TGF-β are positively correlated with the severity of chronic obstructive pulmonary air flow, suggesting that TGF-β and NOX4 signaling may be involved in the development of chronic obstructive pulmonary disease airway remodeling.
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Zhongguo Ying Yong Sheng Li Xue Za Zhi · Jun 2017
[Ameliorative effects and the mechanism of lyceum barbarum polysaccharide on insulin resistance of HepG2 cell].
To observe the effects of lyceum barbarum polysaccharide (LBP) on insulin resistance of HepG2 cells and investigate its possible mechanism. ⋯ Medium and high concentration of LBP can improve insulin resistance of HepG2 cell, its mechanisns may be associated with decreasing the level of oxidative stress and increasing the protein expressions of insulin signaling pathway.