BJOG : an international journal of obstetrics and gynaecology
-
Randomized Controlled Trial Multicenter Study
The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for women at 2 years.
The aim of this study was to assess long-term effects for women following the use of magnesium sulphate for pre-eclampsia. ⋯ The reduction in the risk of eclampsia following prophylaxis with magnesium sulphate was not associated with an excess of death or disability for the women after 2 years.
-
Randomized Controlled Trial Multicenter Study
Magnesium sulphate given before very-preterm birth to protect infant brain: the randomised controlled PREMAG trial*.
To evaluate whether magnesium sulphate (MgSO(4)) given to women at risk of very-preterm birth would be neuroprotective in preterm newborns and would prevent neonatal mortality and severe white-matter injury (WMI). ⋯ Although our results are inconclusive, improvements of neonatal outcome obtained with MgSO(4) are of potential clinical significance. More research is needed to assess the protective effect of MgSO(4) alone or in combination with other neuroprotective molecules.
-
Randomized Controlled Trial Comparative Study
Randomised controlled trial comparing the efficacy of same-day administration of mifepristone and misoprostol for termination of pregnancy with the standard 36 to 48 hour protocol.
To determine the efficacy of oral mifepristone followed by vaginal misoprostol 6 hours later compared with the standard 36- to 48-hour regimen for medical termination of pregnancy. ⋯ Oral mifepristone 200 mg followed by vaginal misoprostol 800 micrograms after 6 hours is not as effective at achieving a complete abortion compared with the 36- to 48-hour protocol.
-
Randomized Controlled Trial Comparative Study
A randomised trial of carbetocin versus syntometrine in the management of the third stage of labour.
Syntometrine is an effective uterotonic agent used in preventing primary postpartum haemorrhage but has adverse effects including nausea, vomiting, hypertension and coronary artery spasm. Carbetocin is a newly developed long-acting oxytocin analogue that might be used as an uterotonic agent. We compare the efficacy and safety of intramuscular (IM) carbetocin with IM syntometrine in preventing primary postpartum haemorrhage. ⋯ IM carbetocin is as effective as IM syntometrine in preventing primary postpartum haemorrhage after vaginal delivery. It is less likely to induce hypertension and has a low incidence of adverse effect. It should be considered as a good alternative to conventional uterotonic agents used in managing the third stage of labour.
-
Randomized Controlled Trial Multicenter Study
Active warming as emergency interventional care for the treatment of pelvic pain.
To assess whether local active warming can lessen acute pelvic pain of gynaecological origin compared with traditional methods in a prehospital setting. ⋯ Local warming is an effective emergency care measure for acute pelvic pain.