BJOG : an international journal of obstetrics and gynaecology
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Early reports of COVID-19 in pregnancy described management by caesarean, strict isolation of the neonate and formula feeding. Is this practice justified? ⋯ Risk of neonatal infection with COVID-19 by delivery route, infant feeding and mother-baby interaction.
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High-quality care for termination of pregnancy (TOP) requires pain to be effectively managed; however, practices differ, and the available guidelines do not specify optimal strategies. ⋯ Although women experience intense pain during second-trimester termination of pregnancy, few data are available to inform their treatment.
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Ordinary meta-analyses indicate that magnesium sulphate (MgSO4 ) treatment in women at imminent risk for preterm delivery decreases the offspring's risk of cerebral palsy (CP). However, repetitive testing of cumulative data calls for statistical caution, e.g. by trial sequential analysis (TSA), for which there are previously insufficient samples to draw a firm conclusion. Recently, a randomised controlled trial (RCT) provided additional data that potentially increased the sample size such that a new TSA might detect a statistically significant effect. ⋯ Antenatal magnesium sulphate decreases the risk of cerebral palsy in children born preterm.
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Meta Analysis
The safety of oral fluconazole during the first trimester of pregnancy: a systematic review and meta-analysis.
Oral fluconazole is used to treat vulvovaginal candidiasis during pregnancy. However, there are concerns regarding the pregnancy outcomes following exposure to fluconazole. ⋯ Oral fluconazole during the first trimester of pregnancy may be associated with unfavourable pregnancy outcomes.