BJOG : an international journal of obstetrics and gynaecology
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Ordinary meta-analyses indicate that magnesium sulphate (MgSO4 ) treatment in women at imminent risk for preterm delivery decreases the offspring's risk of cerebral palsy (CP). However, repetitive testing of cumulative data calls for statistical caution, e.g. by trial sequential analysis (TSA), for which there are previously insufficient samples to draw a firm conclusion. Recently, a randomised controlled trial (RCT) provided additional data that potentially increased the sample size such that a new TSA might detect a statistically significant effect. ⋯ Antenatal magnesium sulphate decreases the risk of cerebral palsy in children born preterm.
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Meta Analysis
The safety of oral fluconazole during the first trimester of pregnancy: a systematic review and meta-analysis.
Oral fluconazole is used to treat vulvovaginal candidiasis during pregnancy. However, there are concerns regarding the pregnancy outcomes following exposure to fluconazole. ⋯ Oral fluconazole during the first trimester of pregnancy may be associated with unfavourable pregnancy outcomes.
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Review Meta Analysis
Influence of race/ethnicity on prevalence and presentation of endometriosis: a systematic review and meta-analysis.
Understanding the impact of race/ethnicity on the prevalence and presentation of endometriosis may help improve patient care. ⋯ Prevalence of endometriosis may be influenced by race/ethnicity, but there is limited quality literature exploring this topic.
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Recent progesterone trials call for an update of previous syntheses of interventions to prevent preterm birth. ⋯ In updated NMA, vaginal progesterone consistently reduced PTB in overall at-risk pregnancies and in women with previous PTB.
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Stillbirth has a profound impact on women, families, and healthcare workers. The burden is highest in low- and middle-income countries (LMICs). There is need for respectful and supportive care for women, partners, and families after bereavement. ⋯ Reducing stigma, promoting respectful care and investigating stillbirth have a positive impact after stillbirth for women and families in LMICs.