BJOG : an international journal of obstetrics and gynaecology
-
Randomized Controlled Trial Multicenter Study
Recurrence of vulval intraepithelial neoplasia following treatment with cidofovir or imiquimod: results from a multicentre, randomised, phase II trial (RT3VIN).
To compare the recurrence rates after complete response to topical treatment with either cidofovir or imiquimod for vulval intraepithelial neoplasia (VIN) 3. ⋯ Long-term data indicates a trend towards response being maintained for longer following treatment with cidofovir than with imiquimod, with similar low rates of adverse events for each drug. Adverse event rates indicated acceptable safety of both drugs TWEETABLE ABSTRACT: Long-term follow up in the RT3VIN trial suggests cidofovir may maintain response for longer than imiquimod.
-
Randomized Controlled Trial Multicenter Study Comparative Study
Misoprostol for cervical priming prior to hysteroscopy in postmenopausal and premenopausal nulliparous women; a multicentre randomised placebo controlled trial.
To evaluate the reduction of pain by misoprostol compared with placebo prior to hysteroscopy in postmenopausal and premenopausal nulliparous women. ⋯ RCT: misoprostol versus placebo prior to hysteroscopy in 149 women significantly reduces some pain parameters.
-
Randomized Controlled Trial Multicenter Study
Preoperative effects of mifepristone for dilation and evacuation after 19 weeks of gestation: a randomised controlled trial.
To evaluate mifepristone as an adjunct to, or replacement for, osmotic dilators for cervical preparation in surgical abortion after 19 weeks of gestation. ⋯ Mifepristone and misoprostol for cervical preparation prior to D&E has potential to reduce barriers to care.
-
To assess the changes in antimüllerian hormone (AMH) levels after ablation for symptomatic uterine fibroids and adenomyosis using ultrasound-guided high-intensity focused ultrasound (USgHIFU). ⋯ HIFU ablation is a safe and effective treatment for patients with uterine fibroids and adenomyosis that does not affect ovarian function.
-
Randomized Controlled Trial Multicenter Study
Diagnostic workup for postmenopausal bleeding: a randomised controlled trial.
To evaluate the effectiveness of hysteroscopy for the detection and treatment of endometrial polyps versus expectant management in women with postmenopausal bleeding (PMB), a thickened endometrium and benign endometrial sampling. ⋯ In women with PMB, hysteroscopy does not reduce recurrent bleeding but is warranted to detect focal malignancy.