BJOG : an international journal of obstetrics and gynaecology
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Randomized Controlled Trial
Intrauterine lignocaine as an anaesthetic during endometrial sampling: a randomised double-blind controlled trial.
To evaluate the effectiveness of intrauterine lignocaine as an anaesthetic during endometrial sampling. ⋯ Transcervical instillation of lignocaine reduced pain during endometrial sampling.
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Randomized Controlled Trial
Effect of uterotonics on intra-operative blood loss during laparoscopy-assisted vaginal hysterectomy: a randomised controlled trial.
To investigate the effectiveness of uterotonics misoprostol and oxytocin on reducing blood loss during laparoscopy-assisted vaginal hysterectomy (LAVH). ⋯ Combined rectal misoprostol and intravenous oxytocin is a feasible and effective method of reducing blood loss and operation time in LAVH.
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Randomized Controlled Trial
A randomised controlled trial to evaluate the effect of self-administered analgesia on women's experience of outpatient treatment at colposcopy.
To evaluate the effect of self-administered isoflurane and desflurane on women's experience of outpatient treatment at colposcopy. ⋯ Satisfaction with outpatient treatment at colposcopy is generally high. The main effect of isoflurane and desflurane evaluated in this trial was to reduce pain. It appeared to be effective for women with clinically significant anxiety and could be offered as an alternative to general anaesthesia.
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To determine the therapeutic efficacy and safety of a nitric oxide (NO) isosorbide dinitrate donor to induce cervical ripening of women with missed abortions before surgical evacuation of the uterus. ⋯ Intracervical administration of 80 mg isosorbide dinitrate in women with missed abortions appears to be effective for cervical ripening prior to surgical evacuation of the uterus. Differences in the incidence of non-serious adverse events are not likely to be clinically significant.
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Randomized Controlled Trial
Pharmacokinetic interaction studies of atosiban with labetalol or betamethasone in healthy female volunteers.
In two separate trials, we studied the concomitant administration of atosiban with labetalol and betamethasone to determine any possibility of a clinically relevant pharmacokinetic interaction. ⋯ The co-administration of atosiban with betamethasone or labetalol had no clinically relevant influence on their bioavailability or tolerability.