BJOG : an international journal of obstetrics and gynaecology
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Randomized Controlled Trial Multicenter Study Clinical Trial
Antisepsis for abdominal hysterectomy: a randomised controlled trial of povidone-iodine gel.
To assess whether infectious morbidity after total abdominal hysterectomy is decreased by the addition of 20 cc povidone-iodine gel at the vaginal apex after the usual vaginal preparation with povidone-iodine solution. ⋯ Povidone-iodine vaginal gel antisepsis led to a 9% relative decrease in overall infectious morbidity after abdominal hysterectomy, which was not statistically significant. Povidone-iodine vaginal gel decreased the risk of pelvic abscess after total abdominal hysterectomy.
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Multicenter Study
Quantifying severe maternal morbidity: a Scottish population study.
To quantify the incidence of severe maternal morbidity in Scotland and determine the feasibility of doing so. ⋯ Categories of severe maternal morbidity can be defined and may provide a useful measure of the quality of maternity services, particularly in developed countries where maternal mortality is very rare. It appears feasible to set up a national reporting system for maternal morbidity, as well as mortality.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Duloxetine versus placebo in the treatment of European and Canadian women with stress urinary incontinence.
To assess the efficacy and safety of duloxetine in women with stress urinary incontinence. ⋯ The findings support duloxetine as a potential treatment for women with stress urinary incontinence.
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Randomized Controlled Trial Multicenter Study Clinical Trial
The ATAC adjuvant breast cancer trial in postmenopausal women: baseline endometrial subprotocol data.
The ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial is a randomised, double-blind trial comparing 'Arimidex' (anastrozole), alone or in combination with tamoxifen, relative to tamoxifen alone as a five year adjuvant treatment for postmenopausal women with early breast cancer. Because tamoxifen is associated with endometrial pathology, the ATAC endometrial subprotocol was initiated to establish the background prevalence of pathology, and to assess prospectively the incidence and nature of intrauterine changes before and following endocrine therapy. ⋯ This is the first study of such size in gynaecologically asymptomatic breast cancer patients. This paper describes the findings in individual patients before any trial treatment was given. In this baseline group, 82% (219/268) of women had a normal endometrial cavity; 18% (49/268) had endometrial activity (proliferative or secretory endometrium in 9%) or an intracavity abnormality (hyperplasia, polyps and a fibroid in 9%). In total, 36% of biopsies had insufficient tissue for diagnosis, which in combination with a normal hysteroscopy was classed as normal. The appearance of a polyp hysteroscopically in this group was not proven histologically in approximately 40% of cases. The development of uterine pathology over time in the ATAC study will subsequently be assessed against the findings of this baseline paper.
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Multicenter Study
The development of a questionnaire to measure the severity of symptoms and the quality of life before and after surgery for stress incontinence.
To develop and validate a short questionnaire recording the severity of symptoms and the quality of life, pre- and post-operatively, in women undergoing surgery for stress incontinence. ⋯ The questionnaire is easy to understand and complete and is a valid and reliable instrument for assessment of the symptoms of incontinence and the quality of life. Pre- and post-operative evaluation of women with stress incontinence was performed in a standardised setting in 22 of the 37 Norwegian departments and the reporting to a national database was successful. Comparison of surgical procedures, departments and surgeons is possible.