BJOG : an international journal of obstetrics and gynaecology
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Randomized Controlled Trial Comparative Study Clinical Trial
Efficacy of preemptive analgesia for wound pain after laparoscopic operations in infertile women: a randomised, double-blind and placebo control study.
To compare preemptive analgesia and preclosure analgesia in reducing wound pain after laparoscopic operation. ⋯ The preclosure analgesia is better than preemptive analgesia and no analgesia in reducing post-operative wound pain.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Duloxetine versus placebo in the treatment of European and Canadian women with stress urinary incontinence.
To assess the efficacy and safety of duloxetine in women with stress urinary incontinence. ⋯ The findings support duloxetine as a potential treatment for women with stress urinary incontinence.
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Randomized Controlled Trial Clinical Trial
ONO-8815Ly, an EP2 agonist that markedly inhibits uterine contractions in women.
To determine the effect of ONO-8815Ly on uterine contractions. ⋯ ONO-8815Ly is a potent inhibitor of spontaneous uterine contractility in non-pregnant women and it reduces the uterine response to oxytocin injections.
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Randomized Controlled Trial Comparative Study Clinical Trial
A randomised controlled trial of ursodeoxycholic acid and S-adenosyl-l-methionine in the treatment of gestational cholestasis.
To compare the efficacy of S-adenosyl-l-methionine and ursodeoxycholic acid in improving serum biochemical abnormalities in gestational cholestasis. ⋯ In women with intrahepatic cholestasis of pregnancy, ursodeoxycholic acid is more effective than S-adenosyl-l-methionine at improving the concentration of serum bile acids and other tests of liver function, whereas both therapies are equally effective at improving pruritus.
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Randomized Controlled Trial Multicenter Study Clinical Trial
The ATAC adjuvant breast cancer trial in postmenopausal women: baseline endometrial subprotocol data.
The ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial is a randomised, double-blind trial comparing 'Arimidex' (anastrozole), alone or in combination with tamoxifen, relative to tamoxifen alone as a five year adjuvant treatment for postmenopausal women with early breast cancer. Because tamoxifen is associated with endometrial pathology, the ATAC endometrial subprotocol was initiated to establish the background prevalence of pathology, and to assess prospectively the incidence and nature of intrauterine changes before and following endocrine therapy. ⋯ This is the first study of such size in gynaecologically asymptomatic breast cancer patients. This paper describes the findings in individual patients before any trial treatment was given. In this baseline group, 82% (219/268) of women had a normal endometrial cavity; 18% (49/268) had endometrial activity (proliferative or secretory endometrium in 9%) or an intracavity abnormality (hyperplasia, polyps and a fibroid in 9%). In total, 36% of biopsies had insufficient tissue for diagnosis, which in combination with a normal hysteroscopy was classed as normal. The appearance of a polyp hysteroscopically in this group was not proven histologically in approximately 40% of cases. The development of uterine pathology over time in the ATAC study will subsequently be assessed against the findings of this baseline paper.