BJOG : an international journal of obstetrics and gynaecology
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Randomized Controlled Trial Multicenter Study
Sequential use of double-balloon catheter and oral misoprostol versus oral misoprostol alone for induction of labour at term (CRBplus trial): a multicentre, open-label randomised controlled trial.
To evaluate the efficacy of inducing labour using a double-balloon catheter and oral misoprostol sequentially, in comparison with oral misoprostol alone. ⋯ The use of a double-balloon catheter on the first day, before starting oral misoprostol on the second day, did not improve the induction to delivery interval and the rate of delivery within 48 hours, in comparison with oral misoprostol alone.
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Multicenter Study
Stillbirth in twins, exploring the optimal gestational age for delivery: a retrospective cohort study.
To evaluate the optimal gestational age at delivery for twins. ⋯ The balance of risk between neonatal death/intrapartum stillbirth and antepartum stillbirth begins to favour delivery at 36 weeks of gestation, particularly in monochorionic diamniotic twins.
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Randomized Controlled Trial Multicenter Study
Psychological morbidity associated with ovarian cancer screening: results from more than 23,000 women in the randomised trial of ovarian cancer screening (UKCTOCS).
To examine the psychological sequelae associated with abnormal screening in the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). ⋯ Screening does not appear to raise anxiety but psychological morbidity is elevated by more intense repeat testing following abnormal annual screens, and in women after surgical treatment for ovarian cancer.
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Randomized Controlled Trial Multicenter Study
Transfusion policy after severe postpartum haemorrhage: a randomised non-inferiority trial.
To assess the effect of red blood cell (RBC) transfusion on quality of life in acutely anaemic women after postpartum haemorrhage. ⋯ Statistically, non-inferiority could not be demonstrated as the confidence interval crossed the non-inferiority boundary. Nevertheless, with only a small difference in physical fatigue and no differences in secondary outcomes, implementation of restrictive management seems clinically justified.
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Randomized Controlled Trial Multicenter Study Comparative Study
A comparison of intramuscular diamorphine and intramuscular pethidine for labour analgesia: a two-centre randomised blinded controlled trial.
Intramuscular (i.m.) pethidine is used worldwide for labour analgesia and i.m. diamorphine usage has increased in the UK in the last 15 years. This trial aims to ascertain the relative efficacy and adverse effects of diamorphine and pethidine for labour pain. ⋯ There is a modest difference between the analgesia provided by diamorphine or pethidine for labour analgesia but diamorphine is associated with significantly longer labours.