Latest Articles
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Deoxyribose nucleic acid (DNA) methylation is an important epigenetic modification that plays an important role in the occurrence and development of tumors. Identifying key methylation-driven genes that affect the prognosis of lung squamous cell carcinoma (LUSC) can provide direction for targeted therapy research. ⋯ Our results indicated that ALDH7A1, a newly discovered MDG in LUSC, could act as an independent prognostic factor for OS in LUSC, with the potential to become a potential target for LUSC diagnosis and treatment. High expression of ALDH7A1 in LUSC could promote the occurrence and development of tumors. Signaling pathways, such as JAK-STAT and mTOR signaling pathways, might regulate the high expression of ALDH7A1.
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In recent years, daratumumab (DARA) has gained widespread use in the treatment of systemic light chain (AL) amyloidosis. In this study, we assessed the efficacy and safety of a DARA treatment strategy based on serum free light chain (sFLC) levels and non-fixed cycles. ⋯ These findings indicate that the sFLC levels based and non-fixed cycle DARA strategy is an efficacious and safe treatment strategy in both newly diagnosed and relapsed/refractory AL amyloidosis.
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Currently, there is a dearth of systematic research data on the phenomenon of false-positive reactions in treponemal tests. The aim of this study is to analyze the clinical characteristics and influencing factors associated with false-positive treponemal tests in patients, so as to enhance the diagnostic accuracy of syphilis and mitigate misdiagnosis-induced incorrect treatment. ⋯ This study demonstrates that the false-positive rate of treponemal tests can be increased by factors such as age, gender, immune diseases, and coagulation disorders. The treponemal antibodies titer level is a valuable reference for assessing false-positive results. To enhance the accuracy of syphilis diagnosis, multiple risk factors should be considered when interpreting results from treponemal tests.
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To evaluate the predictive value of pathological response and lymph node status on progression-free survival (PFS) in patients with potentially resectable non-small cell lung cancer (NSCLC) receiving neoadjuvant immunotherapy. ⋯ In potentially resectable NSCLC, MPR and CPR demonstrate similar PFS benefits after neoadjuvant immunotherapy. Lymph node status significantly influences prognosis, even in initially unresectable cases. The proposed risk stratification provides a valuable tool for personalized management in this challenging patient population.
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Chemoimmunotherapy is the first-line therapy for patients with recurrent or metastatic nasopharyngeal carcinoma (NPC) and is currently the main induction treatment option for patients with locoregionally advanced NPC. However, it remains unclear whether combining immunotherapy with standard induction chemotherapy enhances its efficacy. This study aimed to evaluate the efficacy, toxicity, and survival outcomes of induction chemoimmunotherapy in patients with locoregionally advanced NPC. ⋯ Adding immunotherapy to induction chemotherapy may be an effective and safe choice for treating patients with stage IVa NPC.