Articles: dementia-etiology.
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Multicenter Study
Albuminuria and Estimated GFR as Risk Factors for Dementia in Midlife and Older Age: Findings From the ARIC Study.
Evidence is limited on how estimated glomerular filtration rate (eGFR) and urinary albumin-creatinine ratio (UACR) relate to dementia at different ages. We evaluated eGFR and UACR in midlife and older age as risk factors for dementia. Additionally, we assessed whether the association between eGFR and dementia is altered when cystatin C and β2-microglobulin (B2M) levels are used for GFR estimation. ⋯ Albuminuria was consistently associated with dementia incidence. Lower eGFR based on cystatin C or B2M, but not creatinine, levels was also associated with dementia. Risk associations were similar when kidney measures were assessed at midlife and older age.
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Letter Multicenter Study
BeCaf study: caffeine and behaviour in nursing homes, a study protocol and EBM training program.
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Critical care medicine · May 2014
Randomized Controlled Trial Multicenter StudyInfection Hospitalization Increases Risk of Dementia in the Elderly.
Severe infections, often requiring ICU admission, have been associated with persistent cognitive dysfunction. Less severe infections are more common and whether they are associated with an increased risk of dementia is unclear. We determined the association of pneumonia hospitalization with risk of dementia in well-functioning older adults. ⋯ Hospitalization with pneumonia is associated with increased risk of dementia.
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Multicenter Study
Is postoperative cognitive dysfunction a risk factor for dementia? A cohort follow-up study.
Postoperative cognitive dysfunction (POCD) is a common complication in elderly patients after major surgery. An association between POCD and the development of dementia has been suspected. In this study, we assessed if POCD was a risk factor for the occurrence of dementia. ⋯ POCD was not significantly associated with registered dementia over a median follow-up of 11 yr.
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Am J Geriatr Psychiatry · Dec 2012
Multicenter StudyDepressive symptoms in oldest-old women: risk of mild cognitive impairment and dementia.
Increasing evidence suggests that depression is a risk factor for cognitive impairment, but it is unclear if this is true among the oldest old. We determined whether elevated depressive symptoms predicted 5-year incident mild cognitive impairment (MCI) or dementia, and neuropsychological test performance among oldest-old women. ⋯ Elevated depressive symptoms are an important risk factor for cognitive disorders and lower cognitive performance among women living to their ninth and tenth decades.