Articles: opioid-analgesics.
-
Acta Anaesthesiol Scand · Apr 1988
Randomized Controlled Trial Comparative Study Clinical Trial Controlled Clinical TrialEpidural sufentanil for intra- and postoperative analgesia in thoracic surgery: a comparative study with intravenous sufentanil.
A comparative study was undertaken to evaluate the effectiveness of epidural sufentanil in providing intra- and postoperative analgesia during thoracic surgery. Sufentanil was chosen on the basis of its high lipid solubility and its potent opiate receptor binding. Epidural sufentanil was compared with intravenous sufentanil as the major intraoperative analgetic agent in an anesthesia regimen with midazolam and nitrous oxide. ⋯ Sufentanil provided good analgesia with a very fast onset and a mean duration of almost 7 h. Severe respiratory depression was observed in one patient within 1 h of extubation, probably due to the combined effects of the narcotic administration and residual midazolam. It is concluded that 50 micrograms of sufentanil administered in the thoracic epidural space provides valuable intraoperative analgesia which can easily be extended into the postoperative period, although all necessary precautions for epidural opiate administration should be taken.
-
Comparative Study
Epidural sufentanil for postoperative analgesia after cesarean section.
-
Der Urologe. Ausg. A · Mar 1988
[Peridural opioid analgesia in the terminal stage of cancer. Indications--implementation--results].
The indications for the application of opioids near the spinal cord are presented and two groups of patients treated with pericutaneous and intracorporeal systems are reported. If indicated, this method offers the possibility of treating patients on an outpatient basis.
-
Acta Anaesthesiol Scand · Feb 1988
Clinical Trial Controlled Clinical TrialEfficacy of 0.3 mg morphine intrathecally in preventing tourniquet pain during spinal anaesthesia with hyperbaric bupivacaine.
Tourniquet-induced pain is probably mediated by C-fibres. The ability of morphine to interrupt this nociceptive conduction was studied in a double-blind fashion by administering either morphine 0.3 mg or saline intrathecally along with hyperbaric bupivacaine 15 mg for spinal anaesthesia in 40 patients undergoing orthopaedic surgery on the lower extremity. The block characteristics were similar in both groups. ⋯ The remaining 12 patients in the morphine group had pain responses similar to those patients not given morphine. Intrathecal morphine provides a level of prophylaxis against tourniquet pain. However, the dosage employed here was associated with urinary and emetic side-effects.