Articles: stroke.
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This study explored structural and functional alterations in the whole brain of stroke patients with hemiplegia. ⋯ This study identified key brain regions and characteristics that exhibit structural and functional changes following stroke injury.
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Dizziness is a common clinical presentation that incurs huge financial costs. It is frequently misdiagnosed due to a wide differential involving both benign (inner ear disease) and serious (stroke) disorders. ⋯ This Clinical Progress Note reviews the literature on acute dizziness evaluation in adult patients and presents an evidence-based framework for hospitalists to diagnose the majority of undifferentiated dizzy patients at the bedside. Future research should assess the validity of this approach with hospitalists' ability to accurately diagnose dizzy patients, and its impact on patient care and healthcare outcomes.
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Aims/Background The background for establishing and verifying a dehydration prediction model for elderly patients with post-stroke dysphagia (PSD) based on General Utility for Latent Process (GULP) is as follows: For elderly patients with PSD, GULP technology is utilized to build a dehydration prediction model. This aims to improve the accuracy of dehydration risk assessment and provide clinical intervention, thereby offering a scientific basis and enhancing patient prognosis. This research highlights the innovative application of GULP technology in constructing complex medical prediction models and addresses the special health needs of elderly stroke patients. ⋯ In the validation set, the AUC was 0.867 with a standard error of 0.025 and a 95% CI of 0.694 to 0.934. The optimal cutoff value here was 0.66, with a sensitivity of 80.16% and a specificity of 85.94%. Conclusion This study successfully established and validated a GULP-based dehydration prediction model for elderly patients with dysphagia following a stroke, demonstrating high application value.
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Previous research demonstrated that the numerical Cincinnati Prehospital Stroke Scale (CPSS) identifies large vessel occlusion (LVO) at similar rates compared to dedicated LVO screening tools. We aimed to compare numerical CPSS to additional stroke scales using a national emergency medical services (EMS) database. ⋯ The less complex CPSS exhibited comparable performance to three frequently employed LVO detection tools. The EMS leadership, medical directors, and stroke system directors should weigh the complexity of stroke severity instruments and the challenges of ensuring consistent and accurate use when choosing which tool to implement. The straightforward and widely adopted CPSS may improve compliance while maintaining accuracy in LVO detection.
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Randomized Controlled Trial Multicenter Study Comparative Study
Abelacimab versus Rivaroxaban in Patients with Atrial Fibrillation.
Abelacimab is a fully human monoclonal antibody that binds to the inactive form of factor XI and blocks its activation. The safety of abelacimab as compared with a direct oral anticoagulant in patients with atrial fibrillation is unknown. ⋯ Among patients with atrial fibrillation who were at moderate-to-high risk for stroke, treatment with abelacimab resulted in markedly lower levels of free factor XI and fewer bleeding events than treatment with rivaroxaban. (Funded by Anthos Therapeutics; AZALEA-TIMI 71 ClinicalTrials.gov number, NCT04755283.).