Articles: out-of-hospital-cardiac-arrest.
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Randomized Controlled Trial Multicenter Study
Predictive value of interleukin-6 in post-cardiac arrest patients treated with targeted temperature management at 33°C or 36°C.
Post-cardiac arrest syndrome (PCAS) is characterized by systemic inflammation, however data on the prognostic value of inflammatory markers is sparse. We sought to investigate the importance of systemic inflammation, assessed by interleukin-6 (IL-6) in comatose survivors of out-of-hospital cardiac arrest. ⋯ In patients surviving >24h following cardiac arrest, IL-6 levels were significantly elevated and associated with severity of PCAS with no significant influence of target temperature. High IL-6 levels were associated with increased mortality. Measuring levels of IL-6 did not provide incremental prognostic value.
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Multicenter Study Observational Study
Changes in coagulation during therapeutic hypothermia in cardiac arrest patients.
Therapeutic hypothermia improves neurological outcome in patients resuscitated after out-of-hospital cardiac arrest. The aim was to investigate whether therapeutic hypothermia induced impaired coagulation. ⋯ NCT02179021.
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Multicenter Study Observational Study
Therapeutic hypothermia is independently associated with favourable outcome after resuscitation from outof-hospital cardiac arrest: a retrospective, observational cohort study.
To determine the association between use of therapeutic hypothermia (TH) after resuscitation from out-of-hospital cardiac arrest (OHCA) and neurological outcome. ⋯ The use of TH in patients admitted to ICU after resuscitation following OHCA was independently associated with favourable neurological outcome.
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Randomized Controlled Trial Multicenter Study
Trial of Continuous or Interrupted Chest Compressions during CPR.
During cardiopulmonary resuscitation (CPR) in patients with out-of-hospital cardiac arrest, the interruption of manual chest compressions for rescue breathing reduces blood flow and possibly survival. We assessed whether outcomes after continuous compressions with positive-pressure ventilation differed from those after compressions that were interrupted for ventilations at a ratio of 30 compressions to two ventilations. ⋯ In patients with out-of-hospital cardiac arrest, continuous chest compressions during CPR performed by EMS providers did not result in significantly higher rates of survival or favorable neurologic function than did interrupted chest compressions. (Funded by the National Heart, Lung, and Blood Institute and others; ROC CCC ClinicalTrials.gov number, NCT01372748.).
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Randomized Controlled Trial Multicenter Study
Anxiety and depression among out-of-hospital cardiac arrest survivors.
Survivors of out-of-hospital cardiac arrest (OHCA) may experience psychological distress but the actual prevalence is unknown. The aim of this study was to investigate anxiety and depression within a large cohort of OHCA-survivors. ⋯ One fourth of OHCA-survivors reported symptoms of anxiety and/or depression at 6 months which was similar to STEMI-controls and previous normative data. Subjective cognitive problems were associated with an increased risk for psychological distress. Since psychological distress affects long-term prognosis of cardiac patients in general it should be addressed during follow-up of survivors with OHCA due to a cardiac cause. ClinicalTrials.gov NCT01020916/NCT01946932.