Articles: monitoring.
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This study aimed to investigate the expression of cluster of differentiation 44 (CD44) in prostate adenocarcinoma (PAC) compared to benign prostatic hyperplasia (BPH) to address the need for biomarkers that can aid in grading classification and prognosis. ⋯ This study highlights CD44 expression not only as a potential biomarker for PAC diagnosis but also potential guide to therapeutic decision-making. Patients exhibiting lower CD44 levels may require closer monitoring and more aggressive treatment strategies, while those with higher expression may be candidates for less intensive management. Overall, our findings advocate for further investigation into CD44 as a biomarker for prostate cancer aggressiveness, which could ultimately enhance personalized treatment approaches and improve the patient outcomes.
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J Clin Monit Comput · Feb 2025
Characterizing drivers of change in intraoperative cerebral saturation using supervised machine learning.
Regional cerebral oxygen saturation (rSO2) is used to monitor cerebral perfusion with emerging evidence that optimization of rSO2 may improve neurological and non-neurological outcomes. To manipulate rSO2 an understanding of the variables that drive its behavior is necessary, and this can be accomplished using supervised machine learning. This study aimed to establish a hierarchy by which various hemodynamic and ventilatory variables contribute to intraoperative changes in rSO2. ⋯ CO2 is a significant mediator of changes in rSO2 in an intraoperative setting, through its established effects on cerebral blood flow. This study furthers our overall understanding of the complex physiologic process that governs cerebral oxygenation by quantifying the hierarchy by which rSO2 is affected. Clinical Trial Number NCT01838733 (ClinicalTrials.gov).
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Minerva anestesiologica · Feb 2025
Risk stratification for postoperative hypoxemia among bariatric surgery patients.
Patients with obesity, especially those suffering from obstructive sleep apnea (OSA), are prone to postoperative respiratory hypoxemia. The PRODIGY (prediction of opioid-induced respiratory depression in patients monitored by capnography) Score is used to predict respiratory complications that factor in sleep-disordered breathing. Data on the impact of OSA on the frequency and timing of postoperative desaturation trends after bariatric surgery are lacking. ⋯ Postoperative desaturation rates are significantly higher among patients with OSA with high PRODIGY scores, especially in the delayed postoperative period. Continuous extended postoperative monitoring is warranted for these high-risk patients after bariatric surgery.