Articles: human.
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Am. J. Respir. Crit. Care Med. · Mar 2014
Clinical TrialQuantification of Pulmonary Inflammation after Segmental Allergen Challenge Using TIRM Magnetic Resonance Imaging.
There is a need to develop novel noninvasive imaging biomarkers that help to evaluate antiinflammatory asthma treatments. ⋯ The MRI-based noninvasive TIRM score is a promising biomarker for the noninvasive detection of the inflammatory response after segmental allergen challenge in patients with asthma and may serve to monitor the therapeutic effectiveness of novel antiinflammatory drugs in future human trials.
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Note: Many of the concepts and some of the text and content provided in this paper were developed in association with Knut Ole Sundnes, MD and evolved from the Health Disaster Management: Guidelines for Evaluation and Research in the Utstein Style. * Initial and partial support for this project was provided by the Task Force for Quality Control of Disaster Management. This Project is under the auspices of the World Association for Disaster and Emergency Medicine. Abstract The goals of conducting disaster research are to obtain information to: (1) decrease the human, environmental, and economic losses; (2) decrease morbidity; (3) decrease pain and suffering; and (4) enhance the recovery of the affected population. ⋯ Birnbaum ML , Daily EK , O'Rourke AP , Loretti A. Disaster research/evaluation frameworks, part 1: an overview. Prehosp Disaster Med. 2014;29(2):1-12 .
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Infectious Disease Case Report Posters ISESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMINTRODUCTION: The Milwaukee Protocol was used for a 24 year-old male U.S. soldier who was diagnosed with rabies after being bit by a feral dog in Afghanistan. He did not receive effective post exposure prophylaxis (PEP) for rabies however [1]. ⋯ Our case highlights the first time ECMO was used in rabies. Also, it exemplifies another failed case of the Milwaukee Protocol. Given the lack of efficacy, the protocol should not be used for rabies. A better understanding of rabies pathogenesis is needed in order to develop novel therapies.Reference #1: Jackson AC. Current and future approaches to the therapy of human rabies. Antiviral Res. 2013 Jul;99(1):61-7.Reference #2: Willoughby,R et. Al Survival after Treatment of Rabies with Induction of Coma, N Engl J Med2005; 352:2508-2514DISCLOSURE: The following authors have nothing to disclose: Amritpal Nat, Amitpal Nat, Amit Sharma, Aravind Pothineni, Ioana AmzutaNo Product/Research Disclosure Information.
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Critical care medicine · Mar 2014
Review Meta AnalysisAssessment of Limb Muscle Strength in Critically Ill Patients: A Systematic Review.
To determine the reliability of volitional and nonvolitional limb muscle strength assessment in critically ill patients and to provide guidelines for the implementation of limb muscle strength assessment this population. ⋯ Voluntary muscle strength measurement has proven reliable in critically ill patients provided that strict guidelines on adequacy and standardized test procedures and positions are followed.