Articles: human.
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Within the past decade, the U. S. DoD has increased spending on global health engagements (GHEs). ⋯ Maximizing health care-related programs will bolster a partner government's ability to maintain secure borders and prevent conflict while depriving extremists of safe havens. Looking beyond the short-term benefits, the long-term effects of GHEs are not limited to a nation's borders; aid permeates into a society providing social and economic opportunities otherwise unobtainable to the community and effectively winning the hearts and minds of the population. Although the DoD does list policies and procedures in which to conduct GHEs, the proposed set of principles can further prevent conflicts, deliver better foreign humanitarian assistance, and develop a better health care partnership centered around the host nation.
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Spatial repellent products are used for prevention of insect bites, and a body of evidence exists on spatial repellent entomological efficacy. A new option for vector control, spatial repellent products are designed to release active ingredient into the air for disruption of human-vector contact thereby reducing human exposure to mosquito-borne pathogens. Clinical trials have shown spatial repellent epidemiological efficacy against Aedes-borne viruses but inconclusive outcomes against malaria. We aimed to show and quantify the protective efficacy of spatial repellents in reducing malaria infection incidence in Busia County, Kenya. ⋯ This study was funded by Unitaid to the University of Notre Dame.
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According to the model of the glymphatic system, the directed flow of cerebrospinal fluid (CSF) is a driver of waste clearance from the brain. In sleep, glymphatic transport is enhanced, but it is unclear how it is affected by anesthesia. Animal research indicates partially opposing effects of distinct anesthetics but corresponding results in humans are lacking. Thus, this study aims to investigate the effect of sevoflurane anesthesia on CSF flow in humans, both during and after anesthesia. ⋯ Collectively, our data show that sevoflurane impairs macroscopic CSF flow via a disruption of coherent gGM activity. This effect persists, at least for a short time, after regaining consciousness. Future studies need to elucidate whether this contributes to the emergence of postoperative neurocognitive symptoms, especially in older patients or those with dementia.