Articles: chronic-pain.
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Tactile dysfunction in chronic pain is explained as disruption in somatotopically based processing of stimuli. We hypothesized that people with chronic back pain also demonstrate a spatially defined disruption of tactile processing. ⋯ Spatial representation of vibrotactile stimuli is disrupted in chronic unilateral back pain.
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Previous studies have demonstrated that fractalkine, a newly discovered chemokine, is implicated in spinal cord neuron-to-microglia activation signaling as well as mediation of neuropathic and inflammatory pain via its sole receptor CX3CR1, which is specifically expressed on microglia. However, whether it is involved in bone cancer pain (BCP) and the underlying mechanisms have not been elucidated. ⋯ Furthermore, we demonstrated that blockade of CX3CR1 suppressed the activation of microglia and the expression of p38 mitogen-activated protein kinase (MAPK) in the spinal cord in BCP rats. These results suggest a new mechanism of BCP, in which the microglia CX3CR1/p38 signaling cascade potentially plays an important role in facilitating pain processing in BCP rats.
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Randomized Controlled Trial Comparative Study
A randomized controlled trial on the effectiveness of a classification-based system for subacute and chronic low back pain.
A randomized controlled trial. ⋯ The classification-based system used in this study was not effective for improving physical therapy care outcomes in a population of patients with subacute and chronic low back pain.