Articles: nerve-block.
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Randomized Controlled Trial Comparative Study Clinical Trial
Use of post-tetanic count in assessment of a repetitive vecuronium-induced neuromuscular block.
In order to evaluate the use of the post-tetanic count (PTC) method during repetitive administration of vecuronium, we studied 20 patients allocated randomly to one of two groups: 10 patients received droperidol-fentanyl anaesthesia (control group); 10 other patients were given droperidol-fentanyl anaesthesia modified subsequently by addition of 0.5% isoflurane (isoflurane group). Before tracheal intubation, a bolus dose of vecuronium 0.08 mg kg-1 was given i.v. followed by repeated doses of 0.03 mg kg-1. The twitch response of adductor pollicis was recorded after supramaximal stimulation of the ulnar nerve at the wrist using a Myograph 2000 neuromuscular transmission analyser. ⋯ In the isoflurane group, the relationship between PTC and time to first reaction to TOF stimulation remained unchanged after addition of isoflurane. However, isoflurane caused a significant prolongation of the duration of intense block and a corresponding lower PTC in all patients. We conclude that PTC is a reliable method to evaluate intense neuromuscular block caused by vecuronium, even after repetitive administration of the drug and in combination with 0.5% isoflurane.
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Acta Anaesthesiol Scand · Aug 1990
Randomized Controlled Trial Comparative Study Clinical TrialContinuous blockade of the lumbar plexus after knee surgery: a comparison of the plasma concentrations and analgesic effect of bupivacaine 0.250% and 0.125%.
In 20 patients a continuous block of the lumbar plexus was administered after knee-joint surgery, and the analgesic effect of two different concentrations of bupivacaine was compared. The same volume of bupivacaine was given to both groups of patients: a bolus dose of 0.4 ml/kg, 0.5% or 0.25%, followed by infusion of 0.14 ml/kg/h, 0.25% or 0.125%, respectively, via a catheter placed in the neurovascular fascial sheath of the femoral nerve according to the "3-in-1 block" technique. The median morphine consumption during the first 16 h postoperatively was 6.0 mg when bupivacaine 0.5/0.25% was used and 9.5 mg when 0.25/0.125% was used. ⋯ The visual analogue pain scores were also similar in the two groups (P greater than 0.05). All plasma concentrations were below 4 micrograms/ml, the highest concentration measured being 3.6 micrograms/ml. It is concluded that when used for a continuous block of the lumbar plexus after knee-joint surgery, bupivacaine in a concentration of 0.125% offers the same pain relief as a concentration of 0.25%, and the risk of toxic reactions is reduced.
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Regional anesthesia · Jul 1990
Randomized Controlled Trial Comparative Study Clinical TrialLidocaine hydrocarbonate is not superior to lidocaine hydrochloride in interscalene brachial plexus block.
To determine the effect of carbonation of lidocaine, a comparison of 1.0% lidocaine hydrochloride (HCl) and 1.1% lidocaine hydrocarbonate (CO2), both with 1:200,000 epinephrine, was made in this study of 50 patients receiving interscalene brachial plexus blocks. Sensory block was determined by the response to pinprick in the C2-T2 dermatomes, while motor block was assessed by the development of paresis and paralysis at the shoulder and hand. The percentage of patients developing analgesia (decreased sensation to pinprick) and anesthesia (total absence of sensation to pinprick) at each dermatome level as well as the percentage of patients developing motor block was not significantly different between the two forms of lidocaine. ⋯ At the individual dermatomes, there was no difference in the onset of analgesia except at one dermatome level, C7, which was near the level of local anesthetic injection. Anesthesia onset in each dermatome as well as the onset of motor block did not differ between the two groups. It is concluded that lidocaine CO2 does not offer any significant clinical advantage over lidocaine HCl in interscalene brachial plexus block.
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Regional anesthesia · May 1990
Randomized Controlled Trial Clinical TrialLocal anesthetic efficacy of ropivacaine (LEA 103) in ulnar nerve block.
Ropivacaine (LEA 103) is a new long-acting local anesthetic that in animal experiments has proved to be equally potent but less toxic than bupivacaine. In this controlled double-blind study in man, the dose-response relation of ropivacaine was examined in peripheral nerve block and its potency was compared to that of bupivacaine. Nerve functions during bilateral ulnar nerve block were monitored in 70 normal subjects by a computer-controlled method. ⋯ Its profile of action is uniform for the different fiber groups and resembles that of bupivacaine. Addition of epinephrine does not improve latency or duration of ropivacaine nerve block. Adverse effects attributable to ropivacaine have not been observed.
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Randomized Controlled Trial Comparative Study Clinical Trial
Axillary plexus block using a peripheral nerve stimulator: single or multiple injections.