Articles: acute-pain.
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Randomized Controlled Trial
Duloxetine and Subacute Pain after Knee Arthroplasty when Added to a Multimodal Analgesic Regimen: A Randomized, Placebo-controlled, Triple-blinded Trial.
Duloxetine is effective for chronic musculoskeletal and neuropathic pain, but there are insufficient data to recommend the use of antidepressants for postoperative pain. The authors hypothesized that administration of duloxetine for 15 days would reduce pain with ambulation at 2 weeks after total knee arthroplasty. ⋯ When included as a part of a multimodal analgesic regimen for knee arthroplasty, duloxetine does not reduce subacute pain with ambulation.
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Acta Anaesthesiol Scand · Sep 2016
Randomized Controlled TrialThe effect of chlorzoxazone on acute pain after spine surgery. A randomized, blinded trial.
Chlorzoxazone is a muscle relaxant administered for musculoskeletal pain, and as an analgesic adjunct for post-operative pain. Chlorzoxazone for low back pain is currently not advised due to the lack of placebo-controlled trials. We explored the effect of chlorzoxazone on acute pain after spine surgery. ⋯ No analgesic effect of single-dose chlorzoxazone was demonstrated in patients with acute pain after spine surgery. Based on these findings, chlorzoxazone cannot be recommended for immediate treatment of acute pain after such procedures.
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Randomized Controlled Trial
Global and Situational Relationship Satisfaction Moderate the Effect of Threat on Pain in Couples.
The aim of this study was to test the hypothesis that greater global and situational relationship satisfaction would reduce the negative impact of threatening information on acute pain. ⋯ These findings demonstrate that the interpersonal context is independently related to acute pain and may also alter the effect of threatening information on acute pain.
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Randomized Controlled Trial
Oral pregabalin for postoperative pain relief after third molar extraction: a randomized controlled clinical trial.
The aim of this randomized controlled clinical trial was to evaluate the efficacy and safety of pregabalin administered pre- and postoperatively in patients with pain and swelling due to the surgical removal of impacted lower third molars. ⋯ These findings suggest that pregabalin may be useful to control acute postoperative pain. Adverse effects are known to be reduced at the low pregabalin dose used in our study.