Articles: function.
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Anesthesia and analgesia · Feb 2023
OCP002, a Mixed Agonist of Opioid and Cannabinoid Receptors, Produces Potent Antinociception With Minimized Side Effects.
Increasing attention has been attracted to the development of bifunctional compounds to minimize the side effects of opioid analgesics. Pharmacological studies have verified the functional interaction between opioid and cannabinoid systems in pain management, suggesting that coactivation of the opioid and cannabinoid receptors may provide synergistic analgesia with fewer adverse reactions. Herein, we developed and characterized a novel bifunctional compound containing the pharmacophores of the mu-opioid receptor agonist DALDA and the cannabinoid peptide VD-Hpα-NH2, named OCP002. ⋯ This study demonstrates that OCP002 produces potent and nontolerance-forming antinociception in mice with reduced opioid- and cannabinoid-related side effects, which strengthen the candidacy of bifunctional drugs targeting opioid/cannabinoid receptors for translational-medical development to replace or assist the traditional opioid analgesics.
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Anesthesia and analgesia · Feb 2023
Improving Patient Blood Management Programs: An Implementation Science Approach.
Organized patient blood management (PBM) programs function in numerous hospitals and health systems around the world contributing to improved patient outcomes as well as increased patient engagement, decreased resource use, and reductions in health care costs. PBM "programming" ranges from the implementation of single strategies/initiatives to comprehensive programs led by dedicated clinicians and PBM committees, employing the use of multiple PBM strategies. Frontline health care professionals play an important role in leading, implementing, operationalizing, measuring, and sustaining successful PBM programs. In this article, we provide practical implementation guidance to support key clinical, administrative, leadership, and structural elements required for the safe and comprehensive delivery of care in PBM programs at the local level.
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J Coll Physicians Surg Pak · Feb 2023
Observational StudyThe Role of YAP-JNK in the Mitophagy, Migration, and Invasion of Gastric Cancer.
To determine the function of the YAP-JNK-mitophagy signalling pathway in gastric cancer (GC). ⋯ Gastric cancer, YAP, JNK, Autophagy.
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Revista médica de Chile · Feb 2023
[Reference values and risk factors in the deterioration of the physical fitness of physically active older chilean adults].
Physical fitness assessment of older adults is essential because it is a key component of functional independence and healthy aging. ⋯ Performance of both men and women in the different SFT tests decreased as older adults aged. Age, sex, and BMI were the main risk factors for the deterioration of the physical fitness of physically active older adults.