Articles: amnion-transplantation.
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Clinical spine surgery · Nov 2017
Randomized Controlled TrialCryopreserved Amniotic Membrane Improves Clinical Outcomes Following Microdiscectomy.
Prospective, randomized controlled trial. ⋯ The data demonstrate statistically superior clinical outcomes following lumbar microdiscectomy as measured by ODI and SF-12 (physical composite scale) and a lower rate of recurrent herniation with the use of a cAM tissue graft compared with traditional microdiscectomy.
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Randomized Controlled Trial
Effect of amniotic membrane on graft take in extremity burns.
Several studies have shown that the application of amniotic membrane as a biological dressing in the management of burns is accompanied by rapid re-epithelialisation and healing as it diminishes the oozing of plasma, bacterial count and fluid, protein and heat loss. This study evaluates the effect of amniotic membrane on graft take in split-thickness skin graft of extremity burns. ⋯ Our results show that although the amniotic membrane has no negative impact on graft take, it significantly reduces the duration of complete graft take, which is very important for both the patient and the health-care system.
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Randomized Controlled Trial
Effect of fresh human amniotic membrane dressing on graft take in patients with chronic burn wounds compared with conventional methods.
Burns are among the most devastating forms of injury. Nowadays the standard treatment for deep partial thickness and full-thickness burn is early excision and grafting, but this technique is not always feasible; and this leads to chronicity and microbial colonization of burn wounds. Interesting properties of human amniotic membrane made us use it in management of chronic infected burn wounds. ⋯ Our study showed that human amniotic membrane dressing significantly increases the success rate of graft take in chronic wounds, and it can be recommended as an important dressing in chronic burn wounds management, due to interesting anti-microbial, and better graft take effects.
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Randomized Controlled Trial
Amnion in the treatment of pediatric partial-thickness facial burns.
Wound coverage for second-degree burns remains a clinical challenge. Human amniotic membranes have been used for many years in the treatment of burns; however, no large prospective clinical trials have been published. In this article, we present a novel and standardized procurement and processing method for amnion and investigate, whether the use of this biological dressing is safe and may represent a new therapeutic option for children with partial-thickness facial burns compared to standard topical treatment. ⋯ This study indicates that amnion is safe and has advantages as wound coverage for second-degree facial burns compared to the standard topical ointments. Further studies with the use of amniotic membranes on the trunk and the extremities, as well as for coverage of grafted third-degree burns, have yet to be performed.
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Randomized Controlled Trial Clinical Trial
Fresh amniotic membrane transplantation for conjunctival surface reconstruction.
To determine whether fresh human amniotic membrane can be used to reconstruct the conjunctival detect created during symblepharon lysis. ⋯ Both fresh and preserved human amniotic membrane can be considered an ideal alternative substrate for conjunctival surface reconstruction during removal of severe symblepharon.