Articles: narcotic-antagonists.
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Acta Anaesthesiol Scand · Oct 2006
Naloxone and epinephrine are equally effective for cardiopulmonary resuscitation in a rat asphyxia model.
It is not known whether naloxone is as efficacious as epinephrine during cardiopulmonary resuscitation (CPR). The aim of the study was to compare the effects of naloxone and epinephrine on the outcomes of CPR following asphyxial cardiac arrest in rats. ⋯ The administration of naloxone or epinephrine alone may increase the resuscitation rate, and both drugs are equally effective for CPR in a rat asphyxia model. However, the mechanism by which naloxone produces its efficacy during CPR remains unclear and further experimentation will be necessary.
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Letter Case Reports
Analgesia and sedation in the presence of a naltrexone implant: a novel pharmacological challenge.
In chronic opioid abusers, sedation and analgesia present challenges. We describe two trauma patients with naltrexone implants (depot micro-receptor antagonists that facilitate opioid withdrawal) requiring intensive care. The first patient, a 28-year-old man, sustained chest and pelvic injuries when hit by a motor vehicle. ⋯ Propofol, tramadol and paracetamol proved effective. We wish to notify colleagues of the existence of these implants as they are increasingly widely used, and should be considered when encountering severe opioid resistance. Secondly, their role in managing opioid-dependent physicians appears promising.