Articles: narcotic-antagonists.
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Naloxone frequently is used to treat suspected heroin and opioid overdoses in the out-of-hospital setting. The authors' emergency medical services system has operated a policy of allowing these patients, when successfully treated, to sign out against medical advice (AMA) in the field. ⋯ Giving naloxone to patients with heroin overdoses in the field and then allowing them to sign out AMA resulted in no identifiable deaths within this study population.
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Randomized Controlled Trial Clinical Trial
Effect of combining naloxone and morphine for intravenous patient-controlled analgesia.
An early study showed that a naloxone infusion decreased the incidence of morphine-related side effects from intravenous patient-controlled analgesia. The authors tested the hypothesis that a more convenient combination of morphine and naloxone via patient-controlled analgesia would decrease the incidence of side effects compared to morphine alone. ⋯ There was no benefit from administering naloxone combined with morphine via patient-controlled analgesia.
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Arch. Dis. Child. Fetal Neonatal Ed. · Jul 2003
ReviewNaloxone for narcotic exposed newborn infants: systematic review.
Naloxone, a specific opiate antagonist, is available for the treatment of newborn infants with respiratory depression that may be due to transplacentally acquired opiates. ⋯ There is a need for a randomised controlled trial to determine if naloxone confers any clinically important benefits on newborn infants with respiratory depression that may be due to transplacentally acquired narcotic.
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Am J Health Syst Pharm · Jun 2003
Comparative Study Clinical TrialSafety of enteral naloxone and i.v. neostigmine when used to relieve constipation.