Articles: cations.
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Journal of neurochemistry · May 1992
Development of prolonged focal cerebral edema and regional cation changes following experimental brain injury in the rat.
The present study examined the formation of regional cerebral edema in adult rats subjected to lateral (parasagittal) experimental fluid-percussion brain injury. Animals receiving fluid-percussion brain injury of moderate severity over the left parietal cortex were assayed for brain water content at 6 h, 24 h, and 2, 3, 5, and 7 days post injury. Regional sodium and potassium concentrations were measured in a separate group of animals at 10 min, 1 h, 6 h, and 24 h following fluid-percussion injury. ⋯ Potassium concentrations fell significantly 1 h post injury within the injured cortex (p less than 0.05), whereas significant decreases were not observed until 24 h post injury within the injured hippocampus. Cation alterations persisted throughout the 24-h post injury period. These results demonstrate that regional brain edema and cation deregulation occur in rats subjected to lateral fluid-percussion brain injury and that these changes may persist for a prolonged period after brain injury.
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Aneurysmal subarachnoid hemorrhage (ASAH) can cause sudden death from cardiorespiratory arrest (CRA). Successful resuscitation (SR) allows diagnosis and treatment of survivors. We studied incidences of CRA and the influence of SR in ASAH prognosis. ⋯ CRA is not infrequent after onset of ASAH and occurs more commonly in women with PCA. Most likely, it is due to a very large initial hemorrhage disrupting diencephalic circulatory and respiratory centers. Prognosis of patients suffering CRA from ASAH is dismal and not influenced by SR.
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J Neurosurg Anesthesiol · Mar 1990
Perioperative monitoring of the electrocardiogram during cerebral aneurysm surgery.
Electrocardiographic (ECG) abnormalities occur frequently following a subarachnoid hemorrhage and may also occur intraoperatively and postoperatively in patients undergoing neurovascular procedures. The aim of this study was to assess the relationship between ECG changes and the neurological status of the patient, the size and the location of the aneurysm, and the influence of these changes on the cardiac and neurological outcome. The preoperative ECG was analyzed in 270 patients. ⋯ Intraoperative and postoperative changes occurred in 35 and 65% of the patients, respectively, and were independent of the studied factors. There were no documented cardiac events. The presence of an abnormal preoperative ECG did not influence the neurological outcome of the patient, but fluctuating postoperative changes were associated with a worse outcome.
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Since the beginning of the history of man migraine has been described in all civilizations. It would therefore seem helpful if migraine were to be classified, for diagnostic reasons and in order to study the scientific hypotheses, according to the manifold clinical symptoms, as well as the lack of typical pathophysiological, morphological and biochemical findings. ⋯ On the basis of this classification, the individual forms of migraine are described from the viewpoint of the clinical symptoms. The classification of the International Headache Society represents a good basis for reclassifying headaches, which is still under discussion.
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J. Cardiovasc. Pharmacol. · Jan 1984
A population study on the relationship between blood pressure and the excretion of urinary cations.
The relationships between blood pressure and the 24-h excretion of three urinary cations (Ca2+, K+, and Na+) were investigated in a random sample of 528 adults (greater than or equal to 20 years) inhabitants of two Belgian towns. In these adults both systolic and diastolic blood pressures were strongly and independently correlated with age and body weight. Systolic pressure in women was significantly and positively related to pulse rate. ⋯ In 56 current pill users there was a positive association between systolic pressure and 24-h urinary sodium (p less than 0.01 after adjusting for age, body weight, and pulse rate). The present study indicates that urinary potassium is a consistent and negative predictor of both systolic and diastolic pressures in adult men, whose diastolic pressure is weakly and positively associated with urinary calcium. The positive association between systolic pressure and urinary sodium in current users of contraceptive pills may suggest that their blood pressure becomes responsive to their usual salt intake.