Articles: pain.
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Randomized Controlled Trial Clinical Trial
Fentanyl by constant rate i.v. infusion for postoperative analgesia.
Fentanyl by continuous i.v. infusion (1.5 microgram kg-1 min-1 or 0.5 microgram kg-1 min-1) was compared with placebo infusion as an analgesic regimen for 24 h after hysterectomy. The drugs were infused using a new disposable device which required no external power source. All patients were allowed morphine i.m. if they experienced pain. Patients in the higher dose fentanyl group demanded less i.m. morphine and had better pain relief after operation, without important respiratory depression.
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Acta Anaesthesiol Scand · Feb 1985
Randomized Controlled Trial Comparative Study Clinical TrialCaudal or dorsal nerve block? A comparison of two local anaesthetic techniques for postoperative analgesia following day case circumcision.
Fifty boys presenting for day case circumcision were allocated randomly to receive either caudal analgesia or dorsal nerve block (DNB) to provide postoperative pain relief. Analgesia was assessed by a single, unbiased observer utilising a three-point scale. Subsequently, parents completed a simple questionnaire. ⋯ The incidence of vomiting was significantly lower in the DNB group (P less than 0.05). There was no significant difference in the duration of analgesia, although that produced in the DNB group tended to wane sooner. It is concluded that DNB provides satisfactory analgesia following circumcision and has specific advantages when compared with caudal analgesia.
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Randomized Controlled Trial Clinical Trial
Effects of preoperative teaching on postoperative pain: a replication and expansion.
This study was designed to test the effectiveness of brief relaxation training on postoperative pain, replicating and extending a study of Flaherty and Fitzpatrick (1978). A two-group pre- and post-test experimental design was used to determine if vital signs, analgesic consumption, anxiety, self-reported incisional pain sensation and distress differ in postsurgical patients who have or have not received relaxation training. Seventy-two adult, elective abdominal surgery patients were randomly assigned to treatment groups. ⋯ Vital signs, analgesic consumption and self-reported pain sensation were not altered by relaxation training. These findings only partially agree with those of Flaherty and Fitzpatrick. Additional analyses by type of surgery (cholecystectomy and hysterectomy) showed hysterectomy subjects reported less pain sensation and distress and used less analgesics than cholecystectomy subjects.
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Arzneimittel Forsch · Jan 1985
Randomized Controlled Trial Comparative Study Clinical TrialClinically controlled comparative study of suprofen, pentazocine, and placebo. Experience with intramuscular single doses.
Analgesic effect and tolerability of alpha-methyl-4-(2-thienylcarbonyl)-phenylacetic acid (suprofen, Suprol) 200 mg were compared with pentazocine 30 mg and placebo in 88 patients in moderate to severe postoperative pain. The trial was designed as a randomized single-blind study; the test drugs were in single doses (1 ml ampuls) administered by deep intragluteal injection in the upper outer quadrant. The test population was homogeneous as to anamnestic data; the initial intensity of pain was comparable in all three groups. ⋯ Systemic tolerability was considered good to very good in 97% of the subjects in all three treatment groups, whereas local tolerability was considered poor in 2 patients (6.9%) in the group on suprofen. There were no significant differences between the medications. Two subjects each on suprofen and pentazocine and 1 patient on placebo experienced side effects.
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Randomized Controlled Trial Comparative Study Clinical Trial
Efficacy of patient-controlled versus conventional analgesia for postoperative pain.
Patient-controlled i.v. administration and intramuscular administration of morphine sulfate were compared in a crossover study to determine their relative effectiveness in relieving postoperative pain. Twenty adult patients scheduled for abdominal surgery were randomly assigned to one of two groups; one group received i.v. morphine sulfate for 24 hours using a patient-controlled analgesia (PCA) device, after which they were given morphine sulfate i.m. for 24 hours. The treatment order was reversed for the other group. ⋯ No significant differences in amount of narcotic used, respiratory rate, nausea and vomiting, or levels of activity or sedation were noted for the two regimens. Patients' rankings of the two treatment modes did not differ significantly, but a majority of patients indicated a preference for future use of PCA. In these postoperative patients, administration of i.v. morphine sulfate by PCA was as safe as i.m. administration and possibly more effective in relieving pain.