Articles: pain.
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Acta Anaesthesiol Scand · Dec 1979
Randomized Controlled Trial Comparative Study Clinical TrialComparison of the analgesic dose-effect relationships of nefopam and oxycodone in postoperative pain.
The analgesic dose-effect relationship of nefopam was compared in a double-blind randomised trial with that of oxycodone in immediate postoperative pain. Nefopam 15 mg or oxycodone 4 mg was given every 10 min i.v. (maximum six times) to patients in pain after upper abdominal surgery until their wound pain (scored 0-3) disappeared. The mean pain intensity (PI), initially 2.2 in both groups, descreased by approximately the same extent for up to two doses in both groups (to 1.5 after nefopam 30 mg and to 1.1 after oxycodone 8 mg). ⋯ In the nefopam group, 12 patients (75%) needed further pain relief after the maximal dosage (6 x 15 mg). In these patients, oxycodone (maximally 16 mg) gave satisfactory analgesia. Drowsiness and a decrease in the respiratory rate were the principal side-effects of oxycodone, whereas tachycardia, restlessness, sweating and nausea were more frequent after nefopam.
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Randomized Controlled Trial Comparative Study Clinical Trial
Nefopam in postoperative pain.
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British medical journal · Jul 1979
Randomized Controlled Trial Comparative Study Clinical TrialPostoperative analgesia: a comparison of intravenous on-demand fentanyl with epidural bupivacaine.
In a randomised trial postoperative pain relief was provided by either epidural injections of bupivacaine or an infusion of fentanyl adjusted by the patient to achieve adequate pain relief. Both techniques produced satisfactory analgesia without respiratory depression after peripheral arterial surgery. The technique of infusing intravenously a potent analgesic in a dose adjusted by the patient appears to offer several advantages in postoperative care.
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Randomized Controlled Trial Comparative Study Clinical Trial
Postoperative analgesia after circumcision. A randomized comparison between caudal analgesia and intramuscular morphine in boys.
A randomised blind comparison between caudal analgesia (1.5 mg/kg bupivacaine) and intramuscular morphine (0.15 mg/kg) is reported. Forty boys were studied. Caudal analgesia is shown to be significantly better than morphine by means of a linear analogue scale designed to quantify behaviour immediately after operation.
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Randomized Controlled Trial Clinical Trial Controlled Clinical Trial
Analgesic combinations with orphenadrine in oral post-surgical pain.
Two hundred male and female patients underwent a variety of oral surgical procedures and were treated afterwards in four test groups. They took a combination of orphenadrine (25 mg) and acetaminophen (325 mg), either drug alone, or placebo. A double-blind study design was used. ⋯ Each active drug, in turn, was also significantly better throughout than placebo for pain relief. Sub-groups in each treatment regimen required additional pain relief prior to six hours, with significantly more placebo than orphenadrine-acetaminophen patients needing remedication. Side-effect incidence was very low and randomly distributed among the four groups.