Articles: pain.
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Patients who use on-demand analgesia prefer voice feedback rather than buzzer tones to indicate operation of the apparatus. Twenty-four patients had experience of a patient-controlled analgesia apparatus which incorporated a sophisticated feedback of buzzer tones and a speech synthesizer. Of those who expressed a preference, fifteen preferred the speech synthesizer and only one preferred the buzzer tones. The speech synthesizer is a reliable, inexpensive and simple method of supplying feedback to patients when such apparatus is used.
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1. The contribution of midline medullary bulbospinal neurons to descending inhibition from the locus coeruleus (LC) and the funicular trajectories of coeruleo- and raphe-spinal fibers mediating inhibition of spinal nociceptive transmission were examined in different experiments. Extracellular recordings of lumbar dorsal horn neurons were made in deeply pentobarbital-anesthetized, paralyzed rats. ⋯ The effects of ipsilateral and bilateral ventrolateral funiculus (VLF) lidocaine microinjections on spontaneous and heat-evoked unit activity were examined in other experiments. Spontaneous activity increased following ipsilateral VLF lidocaine microinjections for 13/18 units; decreases and no change in spontaneous activity were observed for three and two units, respectively. Heat-evoked unit activity was increased significantly following ipsilateral VLF lidocaine microinjections.(ABSTRACT TRUNCATED AT 400 WORDS)
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Randomized Controlled Trial Clinical Trial
Effect of i.v. lignocaine on pain and the endocrine metabolic responses after surgery.
Pain intensity, and blood glucose and plasma cortisol concentrations were measured following abdominal hysterectomy in 18 patients allocated randomly to receive either i.v. lignocaine 1.5 mg kg-1 plus 2 mg kg-1 h-1, or saline. The administration of lignocaine resulted in plasma concentrations between 1.5 and 2.0 micrograms ml-1 during the 2-h study period. However, the administration of lignocaine i.v. had no effect on the intensity of pain after surgery, or on the adrenocortical and hyperglycaemic responses to surgery.
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Comparative Study Clinical Trial Controlled Clinical Trial
Epidural hydromorphone: a double-blind comparison with intramuscular hydromorphone for postcesarean section analgesia.