Articles: anesthetics.
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A patient who exhibited a severe reaction to an intravenous agent on one occasion was given a similar anaesthetic on a subsequent occasion without incident. Intradermal testing was carried out and the results are tabulated and discussed.
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The in vitro sensitivities to local anaesthetic blockade of A, B and C nerve fibres in rabbit vagus nerves were examined using a series of structurally similar amino-ester agents which varied in lipid solubility and anaesthetic potency. A fibres were found to be the most sensitive and C fibres the least sensitive to conduction blockade with all the agents, provided that equilibrium blockade was allowed to develop. A correlation existed between the intrinsic anaesthetic potency of the various agents and their lipid solubilities. ⋯ As lipid solubility decreased through the series studied, so the onset of conduction blockade of A fibres was prolonged. It is suggested that this related to decreasing ability to penetrate the lipid diffusion barriers around A fibres. The traditional view that C fibres were more sensitive to block may have arisen because of confusion between absolute sensitivity and rate of development of conduction blockade.
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Comparative Study Clinical Trial
Comparison of local anaesthetic techniques in the reduction of Colles' fracture.
A trial comparing the use of Bier's block and the direct infiltration of the fracture site with local anaesthetic was carried out to assess their effectiveness in the reduction of Colles' fracture. This showed Bier's block to be superior in terms of patient acceptability and in ease of reduction. The results of the reduction were also significantly better using the Bier's block, as judged by the measurement of the residual displacement on the X-ray.
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The authors have developed a method for studying the action of volatile anesthetics in Caenorhabditis elegans (C.e.), a free living nematode. C.e. appears to be a useful model for the study of the influence of genetics on susceptibility to anesthetics. This worm has a small, completely defined nervous system, easily manipulated genetics, and a large number of nervous system mutants. ⋯ HS1 is uncoordinated when not exposed to anesthetics. Like the normal strain (N2) HS1 loses mobility when exposed to anesthetics. The ED50S for various anesthetics in HS1 were as follows: methoxyflurane 0.04%, chloroform 0.52%, halothane 0.85%, isoflurane 4.9%, enflurane 6.0%, fluroxene 10.9%.(ABSTRACT TRUNCATED AT 250 WORDS)
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Arch Ophthalmol Chic · Jun 1985
Retrobulbar anesthesia in strabismus surgery. II. Use of a short-acting anesthetic agent.
Forty-two patients underwent strabismus surgery with a retrobulbar injection of 3% chloroprocaine hydrochloride. In the 18 patients who were followed up in the immediate postoperative period, the average duration of action of 3% chloroprocaine was found to be 2.13 hours. In addition to the advantages of local anesthesia, this short-acting anesthetic permits earlier modifications of adjustable sutures and the earlier discharge of patients on the same day as surgery.