Articles: subarachnoid-hemorrhage.
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Comparative Study
Utility of computed tomography perfusion in detection of cerebral vasospasm in patients with subarachnoid hemorrhage.
Digital subtraction (DS) angiography is the gold standard for detecting cerebral vasospasm after subarachnoid hemorrhage (SAH). Computed tomography (CT) perfusion is a recently developed modality for the evaluation of cerebral hemodynamics. This study was conducted to evaluate the potential of using CT perfusion to detect vasospasm in patients with SAH. ⋯ Computed tomography perfusion is an accurate, reliable, and noninvasive method to detect the presence or absence of vasospasm. It can be used as a tool to help guide the decision to pursue DS angiography with the intent to treat vasospasm.
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Comparative Study
Dissociation between vasospasm and functional improvement in a murine model of subarachnoid hemorrhage.
The efficacy of nimodipine was examined in a murine model of subarachnoid hemorrhage (SAH). End points included the diameter of the lumen of the middle cerebral artery (MCA) and behavioral outcome. An apolipoprotein E (apoE)-mimetic peptide, acetyl-AS-Aib-LRKL-Aib-KRLL-amide, previously shown to have promise in this model was tested both alone and in combination with nimodipine. The effects of carboxyamidotriazole (CAI), a non-voltage-gated calcium channel blocker, were explored using the same animal paradigm. ⋯ These results demonstrate a dissociation between vasospasm and neurological outcomes that is consistent with findings of previous clinical trials.
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J. Neurol. Neurosurg. Psychiatr. · Jan 2006
Early circulating levels of endothelial cell activation markers in aneurysmal subarachnoid haemorrhage: associations with cerebral ischaemic events and outcome.
To investigate the relation of endothelial cell activation with delayed cerebral ischaemia (DCI) and outcome after subarachnoid haemorrhage (SAH). ⋯ Concentrations of sICAM-1, sP-selectin, sE-selectin, and ED1-fibronectin do not predict the occurrence of DCI or outcome. The positive associations of raised early vWf concentrations with ischaemic events and poor outcome after SAH may reflect a predisposition to further ischaemic injury through formation of microthrombi in the cerebral circulation.
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Acta Neurochir. Suppl. · Jan 2006
Controlled Clinical TrialChanges in coagulative and fibrinolytic activities in patients with intracranial hemorrhage.
To investigate whether any changes occur in the coagulative/fibrinolytic cascade in patients with subarachnoid hemorrhage (SAH) or hypertensive intracerebral hemorrhage (HICH). ⋯ Both coagulative and fibrinolytic activities were altered after the onset of SAH. These results demonstrate that the coagulative/fibrinolytic cascade might be activated via different mechanisms in different types of stroke. It remains unclear, however, whether a significant alteration of the fibrinolytic cascade in patients with ROSC-SAH might be a nonspecific phenomenon attributable to the reperfusion after collapse.
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Comparative Study Clinical Trial
[Preoperative sedation with dexmedetomidine in patients with aneurysmal subarachnoid hemorrhage].
Dexmedetomidine could be beneficial for preoperative sedation of patients with aneurysmal subarachnoid hemorrhage (SAH) because of its sympathetic suppressive effect without respiratory depression. ⋯ Preoperative dexmedetomidine infusion is suitable for patients with SAH.