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Created July 27, 2015, last updated almost 9 years ago.
Collection: 32, Score: 1466, Trend score: 0, Read count: 1544, Articles count: 1, Created: 2015-07-27 12:31:04 UTC. Updated: 2015-07-27 12:31:04 UTC.Notes
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Collected Articles
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Review Meta Analysis
Tranexamic acid for traumatic brain injury: a systematic review and meta-analysis.
The antifibrinolytic agent tranexamic acid (TXA) has demonstrated clinical benefit in trauma patients with severe bleeding, but its effectiveness in patients with traumatic brain injury (TBI) is unclear. We conducted a systematic review to evaluate the following research question: In ED patients with or at risk of intracranial hemorrhage (ICH) secondary to TBI, does TXA compared to placebo improve patients' outcomes? ⋯ Pooled results from the 2 RCTs demonstrated statistically significant reduction in ICH progression with TXA and a nonstatistically significant improvement of clinical outcomes in ED patients with TBI. Further evidence is required to support its routine use in patients with TBI.
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