• Naomi K Wallace, Felicity Pollard, Marina Savenkova, and Ilia N Karatsoreos.
• Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA 99164, USA.
• Neuroscience. 2020 Nov 10; 448: 300-310.

AbstractAging is associated with reduced amplitude and earlier timing of circadian (daily) rhythms in sleep, brain function, and behavior. We examined whether age-related circadian dysfunction extends to the metabolic function of the brain, particularly in the prefrontal cortex (PFC). Using enzymatic amperometric biosensors, we recorded lactate concentration changes in the PFC in Young (7 mos) and Aged (19 mos) freely-behaving C57BL/6N male mice. Both Young and Aged mice displayed diurnal and circadian rhythms of lactate, with the Aged rhythm slightly phase advanced. Under constant conditions, the Aged rhythm showed a reduced amplitude not seen in the Young mice. We simultaneously observed a relationship between arousal state and PFC lactate rhythm via electroencephalography, which was modified by aging. Finally, using RT-qPCR, we found that aging affects the daily expression pattern of Glucose Transporter 1 (GLUT-1).Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.

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