• J. Neurol. Neurosurg. Psychiatr. · Nov 2013

    Case Reports

    Atypical Bickerstaff brainstem encephalitis: ataxic hypersomnolence without ophthalmoplegia.

    • Benjamin R Wakerley, Derek Soon, Yee-Cheun Chan, and Nobuhiro Yuki.
    • Department of Medicine, National University Hospital, , Singapore, Singapore.
    • J. Neurol. Neurosurg. Psychiatr.. 2013 Nov 1;84(11):1206-7.

    ObjectiveClinical and immunological evaluation of 'incomplete' Bickerstaff brainstem encephalitis (BBE).MethodsWe studied two patients with postinfectious brainstem syndromes who presented at National University Hospital Singapore. Laboratory work-up included measurement of antiganglioside antibodies.ResultsBoth patients displayed hypersomnolence and cerebellar-like ataxia in the absence of external ophthalmoplegia and carried high serum titres of IgG anti-GQ1b antibodies, strongly indicative of BBE.ConclusionsOphthalmoplegia can be absent or incomplete in BBE, and the absence of this clinical feature should not exclude BBE from the clinicians' differential. Such cases of incomplete BBE could be defined as 'ataxic hypersomnolence without ophthalmoplegia'.

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