Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Nov 2013
The connection between ruptured cerebral aneurysms and odontogenic bacteria.
Patients with ruptured saccular intracranial aneurysms have excess long-term mortality due to cerebrovascular and cardiovascular diseases compared with general population. Chronic inflammation is detected in ruptured intracranial aneurysms, abdominal aortic aneurysms and coronary artery plaques. Bacterial infections have been suggested to have a role in the aetiology of atherosclerosis. Bacteria have been detected both in abdominal and coronary arteries but their presence in intracranial aneurysms has not yet been properly studied. ⋯ This is the first report showing evidence that dental infection could be a part of pathophysiology in intracranial aneurysm disease.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2013
Editorial CommentA nexus between lipids and multiple sclerosis?
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J. Neurol. Neurosurg. Psychiatr. · Nov 2013
Meta AnalysisThe heterogeneity of cognitive symptoms in Parkinson's disease: a meta-analysis.
Several studies have reported heterogeneity in cognitive symptoms associated with specific characteristics of patients with Parkinson's disease (PD). Indeed, researchers have characterised subtypes of patients suffering from PD according to various criteria. Those most frequently used are the type of predominant motor symptoms (tremors or non-tremor symptoms), age at onset and presence of depression. ⋯ These results suggested that PD participants with non-tremor predominant motor symptoms or with depression had more or more severe cognitive impairments. Identification of different subtypes in PD is important for a better understanding of the cognitive symptoms associated with this disease. Better knowing the impact of different features of PD subgroups could help to design more appropriate treatments for patients with PD.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2013
Case ReportsAtypical Bickerstaff brainstem encephalitis: ataxic hypersomnolence without ophthalmoplegia.
Clinical and immunological evaluation of 'incomplete' Bickerstaff brainstem encephalitis (BBE). ⋯ Ophthalmoplegia can be absent or incomplete in BBE, and the absence of this clinical feature should not exclude BBE from the clinicians' differential. Such cases of incomplete BBE could be defined as 'ataxic hypersomnolence without ophthalmoplegia'.