• Anesthesiology · Jul 2013

    Review Meta Analysis

    Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.

    Peri-operative systemic magnesium reduces postoperative pain and opioid consumption, although it is of uncertain clinical significance.

    pearl
    • Gildasio S De Oliveira, Lucas J Castro-Alves, Jamil H Khan, and Robert J McCarthy.
    • Department of Anesthesiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA. g-jr@northwestern.edu
    • Anesthesiology. 2013 Jul 1;119(1):178-90.

    BackgroundSystemic magnesium has been used to minimize postoperative pain with conflicting results by clinical studies. It remains unknown whether the administration of perioperative systemic magnesium can minimize postoperative pain. The objective of the current investigation was to evaluate the effect of systemic magnesium on postoperative pain outcomes.MethodsA wide search was performed to identify randomized controlled trials that evaluated the effects of systemic magnesium on postoperative pain outcomes in surgical procedures performed under general anesthesia. Meta-analysis was performed using a random-effect model. Publication bias was evaluated by examining the presence of asymmetric funnel plots using Egger regression.ResultsTwenty randomized clinical trials with 1,257 subjects were included. The weighted mean difference (99% CI) of the combined effects favored magnesium over control for pain at rest (≤4 h, -0.74 [-1.08 to -0.48]; 24 h, -0.36 [-0.63 to -0.09]) and with movement at 24 h, -0.73 (-1.37 to -0.1). Opioid consumption was largely decreased in the systemic magnesium group compared with control, weighted mean difference (99% CI) of -10.52 (-13.50 to -7.54) mg morphine IV equivalents. Publication bias was not present in any of the analysis. Significant heterogeneity was present in some analysis, but it could be partially explained by the sole intraoperative administration of magnesium compared with the intraoperative and postoperative administration. None of the studies reported clinical toxicity related to toxic serum levels of magnesium.ConclusionSystemic administration of perioperative magnesium reduces postoperative pain and opioid consumption. Magnesium administration should be considered as a strategy to mitigate postoperative pain in surgical patients.

      Pubmed     Full text  

      Add institutional full text...

    This article appears in the collections: Regional stuff, Magnesium for fun, and The wonderful world of perioperative magnesium.

    Notes

    pearl
    1

    Peri-operative systemic magnesium reduces postoperative pain and opioid consumption, although it is of uncertain clinical significance.

    Daniel Jolley  Daniel Jolley
     
    Do you have a pearl, summary or comment to save or share?
    250 characters remaining
    help        
    You can also include formatting and links in your notes
    • Simple formatting can be added to notes, such as _italic_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)

    hide…

Want more great medical articles?

Keep up to date with a free trial of metajournal, personalized for your practice.
795,009 articles already indexed!

We guarantee your privacy. Your email address will not be shared.