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  • The wonderful world of perioperative magnesium

    Magnesium
     
    • Review

      Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.

      Anesthesiology. 2013 Jul 1;119(1):178-90.

      Peri-operative systemic magnesium reduces postoperative pain and opioid consumption, although it is of uncertain clinical significance.

      pearl
    • Randomized Controlled Trial

      Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial.

      Lancet. 2002 Jun 1;359(9321):1877-90.

      Magnesium sulphate halves the risk of eclampsia in pre-eclamptic pregnant women without significant adverse effect.

      pearl
    • Randomized Controlled Trial

      The effect of magnesium sulphate infusion on the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane anaesthesia.

      Anaesthesia. 2013 Oct 1;68(10):1045-52.

    expand and show 1 more article

       

    Daniel Jolley.

    4 articles.

    Created May 21, 2015, last updated 7 months ago.

    Private Empty Deleted


    Collection: 20, Score: 1840, Trend score: 0, Read count: 1929, Articles count: 4, Created: 2015-05-21 04:28:25 UTC. Updated: 2023-05-21 23:44:15 UTC.

    Notes

     
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    Collected Articles

    • Anesthesiology · Jul 2013

      Review Meta Analysis

      Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.

      Peri-operative systemic magnesium reduces postoperative pain and opioid consumption, although it is of uncertain clinical significance.

      pearl

      expand abstract… or not…

    • Lancet · Jun 2002

      Randomized Controlled Trial Multicenter Study Clinical Trial

      Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial.

      Magnesium sulphate halves the risk of eclampsia in pre-eclamptic pregnant women without significant adverse effect.

      pearl

      explore further… or not…

    • Anaesthesia · Oct 2013

      Randomized Controlled Trial

      The effect of magnesium sulphate infusion on the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane anaesthesia.

      This randomised, controlled, double-blind study investigated the effects of intra-operative magnesium sulphate administration on the incidence of emergence agitation in children undergoing adenotonsillectomy using sevoflurane anaesthesia. Seventy children were randomly allocated to receive a 30 mg.kg(-1) bolus of intravenous magnesium sulphate after induction of anaesthesia followed by a continuous infusion of 10 mg.kg(-1).h(-1) or an equal volume of saline 0.9%. All children received titrated sevoflurane anaesthesia adjusted to maintain haemodynamic stability. ⋯ Emergence agitation was more common in the control group than in the magnesium group (23 (72%) and 12 (36%), respectively (p = 0.004)), with a relative risk of 0.51 (95% CI 0.31-0.84), an absolute risk reduction of 0.35 (95% CI 0.10-0.54), and number needed to treat of 3 (95% CI 2-9). Postoperative pain scores were comparable in the two groups. Magnesium sulphate reduces the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane anaesthesia and is not associated with increased postoperative side-effects or delayed recovery.

      read more… mark as read…

    • Magnes Res · Sep 2005

      Review Comparative Study

      Magnesium chloride or magnesium sulfate: a genuine question.

      MgSO4 is routinely used in therapeutics despite its toxicity. The aim of the present review was to compare MgSO4 and MgCl2 effects in order to answer the question whether MgSO4 could be or not replaced by MgCl2. Considering that the two salts have both similar and proper effects, a clear-cut conclusion is not easy to draw. However, choosing MgCl2 seems advisable because of its more interesting clinical and pharmacological effects and its lower tissue toxicity as compared to MgSO4.

      read more… or not…

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