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- Ana Maria Obregón Rivas, Jose L Santos, Macarena A Valladares, Jameson Cameron, and Gary Goldfield.
- Escuela de Nutrición y dietética, Facultad de Ciencias para el cuidado de la Salud, Universidad San Sebastián, Concepción, Chile. Electronic address: Aniobregon@gmail.com.
- Nutrition. 2018 Oct 1; 54: 105-110.
ObjectivesThe aim of this study was to assess the association between the single-nucleotide polymorphism rs9939609 in the FTO gene and homeostatic/non-homeostatic eating behavior patterns in Chilean children.MethodsA cross-sectional study was conducted in 258 children (44% female; 8-14 y of age). Anthropometric measurements (weight, height, Z-score of height, body mass index, and waist circumference) were performed. Eating behavior was assessed using the Eating in Absence of Hunger Questionnaire; the Child Eating Behavior Questionnaire; the Three Factor Eating Questionnaire, and the Food Reinforcement Value Questionnaire. Genotype of rs9939609 was determined by a Taqman assay. Association of rs9939609 with eating behavior was assessed using non-parametric tests.ResultsAllelic frequencies of rs9939609 were estimated as 77% for the A allele and 23% for the T allele. We found that normal-weight girl A carriers had higher scores of Satiety Responsiveness and Slowness on the Eating subscale. Normal-weight boy A carriers showed significantly higher scores on the Negative Affect and lower scores of the Desire to Drink subscale. In overweight children, A carriers showed higher scores on the Food Responsiveness, Emotional Overeating, Enjoyment of Food, and Food Choice subscales and lower scores on the Satiety- Responsiveness and Slowness in Eating subscales. In obese children, we found higher scores on the Cognitive Restrained subscale and lower Food Choice.ConclusionThe rs9939609 A allele of the FTO gene is associated with eating behavior traits and may predispose to obesity.Copyright © 2018 Elsevier Inc. All rights reserved.
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