• Nutrition · Feb 2019

    Multigenerational effects of dietary macronutrient intake on the metabolic phenotype of male Wistar rats.

    • Temitope Gabriel Adedeji, Adesoji Fasanmade, and Emiola Olapade-Olaopa.
    • Federal University of Technology, Akure, Nigeria. Electronic address: topeadedeji@gmail.com.
    • Nutrition. 2019 Feb 1; 58: 125-133.

    ObjectivesGene-nutrient interactions are implicated in metabolic phenotypes like metabolic syndrome. The aim of this study was to examine the effects of diet-induced metabolic phenotypes in rats and investigate the effects of these phenotypes in three successive generations.MethodsThree generations of rats were fed on different diets and mated. Blood glucose, adiposity, lipid profile, insulin, adipocytokines, ghrelin, and corticosterone concentrations were determined in F0, F1, and F2 generations using standard methods.ResultsIn comparison with control across generations, glucose (32%), triacylglycerols (52%), and insulin (10%) were significantly elevated in the high-fat diet (HFD)-fed rats; total cholesterol was higher in HFD and high-carbohydrate diet (HCD)-fed groups; whereas high density lipoprotein was higher in the HFD rats but lower in the HPD rats. Adipocytokines were significantly higher in the HCD and HFD groups but lower in the high-protein diet group, whereas ghrelin only declined in HFD rats.ConclusionThis study revealed that different dietary macronutrients induced distinctive metabolic phenotypes, which had variable effects in different generations.Copyright © 2018 Elsevier Ltd. All rights reserved.

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