Ugeskrift for laeger
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Ugeskrift for laeger · Jan 2002
Review Meta Analysis[Palliative chemotherapy in patients with metastatic colorectal cancer].
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Ugeskrift for laeger · Jan 2002
Meta Analysis Comparative Study[What is the effect of placebo interventions? A systematic review of randomized clinical trials with placebo treated and untreated patients].
Placebo treatments have been reported to help patients with many diseases, but the quality of the evidence supporting this belief has not been rigorously evaluated. ⋯ We found no reliable evidence that placebo treatments in general had effects of clinical importance.
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Ugeskrift for laeger · May 2001
Meta Analysis[Long-term oxygen therapy (LTOT) in chronic obstructive lung disease (COL)].
A substantive amendment to this systematic review was last made on 12 April 1999. Cochrane reviews are regularly checked and updated if necessary. ⋯ Four randomised controlled trials were identified. Data from none of these trials could be aggrigated because of differences in trial design and patient selection. Trial 1, continuous oxygen therapy versus nocturnal oxygen therapy: there was a significant improvement in mortality after 24 months (Peto odds ratio 0.45, 95% confidence interval 0.25 to 0.81). Trial 2, oxygen versus no oxygen: there was a significant improvement over five years in mortality in the group receiving oxygen (Peto odds ratio 0.42, 95% confidence interval 0.18 to 0.98). Trial 3, nocturnal oxygen versus no oxygen in patients with arterial desaturation at night: there was no difference in mortality at 36 months. Trial 4, long term oxygen versus no oxygen in moderate hypoxaemia: there was no effect on survival for up to three years of follow up. REVIEWERS' CONCLUSION: Long term oxygen therapy improves survival in a selected group of COPD patients with severe hypoxaemia (arterial PO2 less than 8.0 kPa). Long term oxygen does not appear to improve survival in patients with moderate hypoxia or those who only have arterial desaturation at night.
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Ugeskrift for laeger · Oct 1994
Randomized Controlled Trial Meta Analysis Comparative Study Clinical Trial[Low molecular weight heparin versus unfractionated heparin in the treatment of deep venous thrombosis--a meta-analysis].
A review based on 17 randomised studies on low molecular weight heparin (LMWH) versus unfractionated heparin (UFH) in the treatment of objectively verified deep venous thrombosis (DVT) is presented. Long-term treatment with LMWH was compared with long-term UFH in two studies and with warfarin in one study. In the rest of the studies LMWH and UFH were used during initiation of oral anticoagulant therapy, and these studies were included in a meta-analysis. ⋯ There was no significant difference in the reduction of Marder score during treatment (LMWH 5.0 versus UFH 3.8) or in the frequency of new symptomatic, scintigraphically or angiographically verified pulmonary embolism (LMWH 0.6% versus UFH 1.1%). The frequency of complications seemed independent of whether LMWH was administered once or twice daily. Monitoring of LMWH treatment is not considered necessary but determination of anti-factor Xa in plasma is recommended if bleeding occurs during treatment with LMWH.