Medicina clinica
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Randomized Controlled Trial
Comparison of two antifibrotic treatments for lung fibrosis in post-COVID-19 syndrome: A randomized, prospective study.
Although pulmonary fibrosis secondary to COVID-19 infection is uncommon, it can lead to problems if not treated effectively in the early period. This study aimed to compare the effects of treatment with nintedanib and pirfenidone in patients with COVID-19-related fibrosis. ⋯ In patients with interstitial fibrosis after COVID-19 pneumonia, both nintedanib and pirfenidone were observed to be effective in improving radiological score and PFT parameters. Nintedanib was more effective than pirfenidone in increasing exercise capacity and saturation values but caused more adverse drug effects.
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Randomized Controlled Trial
Physical training program for people at risk of cardiovascular disorders in the primary care setting: A randomized clinical trial.
The impact of a physical training program on moderate-vigorous physical activity is still poorly known in primary cardiovascular prevention. Our objective was to determine the efficacy of a physical training program to promote moderate-vigorous physical activity and exercise in individuals at risk of suffering a cardiovascular event. ⋯ A short-duration physical training program performed in the primary care setting is efficacious and safe in promoting moderate-vigorous physical activity and exercise in the short-term, in a population at risk of suffering a cardiovascular event.
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Randomized Controlled Trial
Impact of clinical ultrasound in patients with heart failure treated in home.
In Spain, more than 10% of patients discharged with acute heart failure (AHF) are readmitted in the first 30 days. This study is designed to assess whether the treatment of AHF guided by clinical ultrasound (CU) in the setting of hospitalization at home (HAH) reduces the incidence of readmission and mortality compared to the standard care (SC). ⋯ Our results suggest that in HAH, a CE guided strategy for AHF could reduce the risk of readmission and mortality compared to SC alone. However, studies with greater statistical power are needed to confirm these results.
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Randomized Controlled Trial
The hemodynamic effects of diazepam versus dexmedetomidine in the treatment of alcohol withdrawal syndrome: A randomized clinical trial.
Dexmedetomidine (DEX) is an alpha-2 adrenergic drug used for short sedation and as an alternative to diazepam (DZP) in the treatment of alcohol withdrawal syndrome (AWS). ⋯ Although DEX is not indicated for the routine treatment of AWS, this study proposes a positive effect on HR, SBP and fewer days of treatment compared to the standard DZP treatment for AWS. Clinical Trials.gov ID: NCT03877120-https://clinicaltrials.gov/ct2/show/NCT03877120.
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Randomized Controlled Trial
Impact of a comprehensive functional rehabilitation programme on the quality of life of the oncological patient with dyspnoea.
Dyspnoea is one of leading causes of loss of autonomy in patients with advanced-stage cancer. Pharmacological measures achieve a reduction of the symptom, but without generalizing this improvement to functionality. We propose the inclusion of a comprehensive functional rehabilitation programme. The purpose is to test the efficacy of an integral respiratory rehabilitation programme to improve autonomy levels and relieve cancer-related dyspnoea. ⋯ Non-pharmacological interventions using a comprehensive functional rehabilitation programme improve functionality and relieve dyspnoea in cancer patients.